Publications by authors named "Elena A Ganina"
Microorganisms
August 2021
Article Synopsis
- The study investigates the virulence of two clinical strains of the Beijing genotype associated with drug-resistant tuberculosis in C57BL/6 mice, highlighting their correlation to global health issues.
- Strains 267/47 (pre-XDR) and 120/26 (MDR) showed differing survival rates in infected mice, with 10% and 40% survival, respectively, compared to 70% for the H37Rv strain.
- Comparison of immune responses revealed significant differences in cytokine gene expression, particularly with downregulated pro-inflammatory and anti-inflammatory genes in mice infected with the more virulent strain 267/47.
Article Synopsis
- The Central Asia Outbreak (CAO) clade is a serious public health concern in Central Asia, featuring strains that are both multidrug-resistant and highly transmissible.
- Research using C57Bl/6 mice revealed that those infected with the drug-resistant Rostov strain died within 48 days, while a more traditional strain, H37Rv, had better survival rates.
- Analysis of lung and liver tissues showed different pathological effects from the two strains, with the Rostov strain causing a higher bacterial load and severe physical depletion in infected mice.
