Oral surgery during Byzantine times.

The Byzantine World covers the eleven-century period between 323-1453 AD and was characterized by a comprehensive system of medicine based on the fundamental principles of Ancient Greek medicine. Several clinical entities, such as epulis, parulis, constrictions of the tongue (short frenum), sublingual ranula, jaws fractures and disclocations, oral fistulae were well-known and treated during the Byzantine period with primarily surgical, but also non-surgical, interventions. Tooth extractions and operations on the uvula were also popular.

Cyclin D1 protein tissue detection in laryngeal cancer.

Cyclin D1 (CCND1) is a set of periodic regulatory proteins that is believed to govern cell cycle transit from G1 into S phase. Overexpression of CCND1 leads to abnormal cellular proliferation which underlies processes of tumorigenesis; CCND1 can thus function as a cooperative oncogene in cell transformation. In the present study we investigate the immunohistochemical expression of CCND1 in a well-documented series of 58 laryngeal squamous cell carcinomas (LSCC) and search for statistical associations between CCND1 index and various clinicopathological parameters including several immunomarkers' expression as well as patients' disease-free survival.

Chondrotympanoplasty: a modified technique of cartilage graft tympanoplasty.

Background: Although the temporalis fascia has been widely used since 1957as a graft in tympanoplasty, it can eventually become thin and atrophic. In addition, due to the lack of elasticity and resistance to pressure changes in the external ear canal, secondary perforations may also develop. Therefore, several authors have suggested that temporalis fascia should be strengthened by periosteum or replaced by cartilage.