Publications by authors named "Eleanor Yuen-Yuen Ong"
Article Synopsis
- Breast cancer is a serious illness that leads to many deaths, and there is a need for new treatments.
- Lapatinib is a new medication that helps people with a specific type of breast cancer that has a lot of HER2 proteins.
- Studies showed that using lapatinib can help patients live longer and have better results compared to treatments without it.
Novel therapeutic strategy for breast cancer: mammalian target of rapamycin inhibition.
Expert Opin Drug Discov
April 2009
Background: Mammalian target of rapamycin (mTOR) plays a central role in regulating cellular protein synthesis. Dysregulation of mTOR signaling pathway is strongly associated with tumorigenesis, angiogenesis, tumor progression and drug resistance. Inhibition of mTOR might not only promote cell cycle arrest, but also sensitize resistant cancer cells to chemotherapeutic and other targeted agents.
View Article and Find Full Text PDFVinflunine: clinical perspectives of an emerging anticancer agent.
Expert Opin Investig Drugs
April 2008
Background: Vinflunine is a novel second generation of Vinca alkaloid. The binding of vinflunine to tubulin and subsequent cellular arrest in mitosis is the core mechanism of this antineoplastic agent. In addition, its potential vascular-disrupting and antiangiogenic activities uphold further clinical development of this compound.
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