Publications by authors named "Eleanor Tuck"
Article Synopsis
- The study examines the lifetime of PSD95 protein in synapses, crucial for signaling, maintenance, and memory, creating the Protein Lifetime Synaptome Atlas.
- PSD95 lifetimes vary significantly, with short lifetimes seen in young mice and areas linked to innate behaviors, while long lifetimes are found in regions related to memory, like the cortex and CA1.
- Interestingly, protein lifetime increases in mouse models of autism and schizophrenia, highlighting its role in synapse diversity and implications for brain development, aging, and neurological disorders.
Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer's disease. Mutations in the sorting receptor-encoding gene SORL1 cause autosomal-dominant Alzheimer's disease, and SORL1 variants increase risk for late-onset AD. To understand the contribution of SORL1 mutations to AD pathogenesis, we analyze the effects of a SORL1 truncating mutation on SORL1 protein levels and endolysosome function in human neurons.
View Article and Find Full Text PDFDirected differentiation of human pluripotent stem cells varies in specificity and efficiency. Stochastic, genetic, intracellular, and environmental factors affect maintenance of pluripotency and differentiation into early embryonic lineages. However, factors affecting variation in in vitro differentiation to defined cell types are not well understood.
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