Anti-inflammatory medication use associated with reduced delirium risk and all-cause mortality: A retrospective cohort study.

Objective: To investigate the relationship between history of anti-inflammatory medication use and delirium risk, as well as long-term mortality.

Methods: In this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Information about anti-inflammatory medication use history including aspirin, NSAIDs, glucosamine, and other anti-inflammatory drugs, was collected.

The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study.

Purpose: Metformin has been reported to improve age-related disorders, including dementia, and to lower mortality. This study was conducted to investigate whether metformin use lower delirium risk, as well as long-term mortality.

Methods: In this retrospective cohort study, previously recruited 1,404 subjects were analyzed.

The genome-wide DNA methylation profiles among neurosurgery patients with and without post-operative delirium.

Aims: There is no previous study demonstrating the differences of genome-wide DNA methylation (DNAm) profiles between patients with and without postoperative delirium (POD). We aimed to discover epigenetic (DNAm) markers that are associated with POD in blood obtained from patients before and after neurosurgery.

Methods: Pre- and post-surgical blood DNA samples from 37 patients, including 10 POD cases, were analyzed using the Illumina EPIC array genome-wide platform.

Evaluation of point-of-care thumb-size bispectral electroencephalography device to quantify delirium severity and predict mortality.

Background: We have developed the bispectral electroencephalography (BSEEG) method for detection of delirium and prediction of poor outcomes.

Aims: To improve the BSEEG method by introducing a new EEG device.

Method: In a prospective cohort study, EEG data were obtained and BSEEG scores were calculated.

Bondi and beyond. Lessons from three waves of COVID-19 from 2020.

Objectives: To describe local operational aspects of the coronavirus disease 2019 (COVID-19) response during the first three waves of outbreaks in New South Wales (NSW), Australia, which began in January, July and December 2020. Type of program or service: Public health outbreak response.

Methods: Narrative with epidemiological linking and genomic testing.

Mortality among patients with sepsis associated with a bispectral electroencephalography (BSEEG) score.

We have previously developed a bispectral electroencephalography (BSEEG) device, which was shown to be effective in detecting delirium and predicting patient outcomes. In this study we aimed to apply the BSEEG approach for a sepsis. This was a retrospective cohort study conducted at a single center.

DNA methylation in the TNF-alpha gene decreases along with aging among delirium inpatients.

It has been suggested that aging and inflammation play key roles in the development of delirium. In the present study, we investigated the differences of the DNAm patterns in the TNF gene between patients with delirium and without. The data and samples derived from previous and ongoing cohort studies were analyzed.

New Cutoff Scores for Delirium Screening Tools to Predict Patient Mortality.

Background/objectives: Detecting delirium is important to identify patients with a high risk of poor outcomes. Although many different kinds of screening instruments for delirium exist, there is no solid consensus about which methods are the most effective. In addition, it is important to find the most useful tools in predicting outcomes such as mortality.

Notifications of imported malaria in Western Australia, 1990-2001: incidence, associated factors and chemoprophylaxis.

Objective: To assess changes in and factors associated with recent malaria notifications in Western Australia (WA).

Design: Retrospective analysis of the WA Notifiable Infectious Diseases Database and enhanced surveillance questionnaires completed by attending medical practitioners.

Patients: Cases of malaria notified between January 1990 and December 2001.

The Role of Nurses in Primary Care: Managing Alcohol-Abusing Patients.

Nurses work on the front lines of primary health care delivery in many settings. The unique characteristics of nursing care put nurses in an excellent position to identify, assess, counsel, and monitor clients with alcohol problems.