Publications by authors named "Eleanor Shelly"
Ann N Y Acad Sci
March 2023
Article Synopsis
- * The research identified optimal buffer conditions (pH 5.62 with phosphate and pH 6.85 with histidine) and determined that lower salt concentrations improved stability by reducing hydrophobic interactions.
- * Among stabilizers, Tween 20 and sugars like trehalose and sucrose enhanced thermal stability, leading to a final formulation that showed increased stability, but further research is needed to assess stability at higher concentrations.
Article Synopsis
- Recent research highlights follicle-stimulating hormone (FSH) as a target for treating diseases like osteoporosis, obesity, and Alzheimer's, with findings showing that blocking FSH can prevent various health issues in mice.
- The development of a humanized FSH-blocking antibody called MS-Hu6 has shown promise in preventing osteoporosis in mice and has safe initial testing in monkeys, demonstrating effective localization to bone and bone marrow.
- MS-Hu6 has been optimized for stability and safety, showing no immunogenic responses in human cell cultures, making it ready for potential future human clinical trials.
