Publications by authors named "Eleanor O'Neill"
Article Synopsis
- The study evaluated the impact of a blast injury on intra-compartmental pressure (ICP) in the lower leg of pigs, aiming to create a more natural model of acute compartment syndrome (ACS).
- Researchers induced a tibial fracture and simulated a blast injury, monitoring ICP and comparing injured limbs to control legs.
- Results showed that blast injuries significantly elevated ICP, with sustained high pressures observed even at 48-72 hours post-injury, despite not needing external manipulation to achieve these levels.
Aim: Perinatal asphyxia is associated with multi-organ injury including acute kidney injury (AKI). New urinary biomarkers may detect more subtle renal injury.
Methods: Urinary biomarkers (albumin, beta-2 microglobulin, cystatin-C, epidermal growth factor, neutrophil gelatinase-associated lipocalin, osteopontin, uromodulin) were serially measured from days 1 to 7 in term infants with perinatal asphyxia and controls and compared to 'Kidney Disease Improving Global Outcome' scoring of renal injury and to encephalopathy grade.