Publications by authors named "Eleanor Henshaw"
Novel inhibitors of the alphavbeta3 integrin--lead identification strategy.
Bioorg Med Chem Lett
August 2009
Article Synopsis
- The text presents a new method for inhibiting the alphavbeta3 integrin, which is a protein that plays a role in various biological processes.
- This approach focuses on using specially designed compounds that achieve nanomolar (nM) potency, meaning they are very effective at low concentrations.
- Importantly, this method does not rely on the traditional arginine binding site for its effectiveness, suggesting a novel mechanism of action.