Publications by authors named "Eleanor Groves"
Pathogenic Yersinia species neutralize innate immune mechanisms by injecting type three secretion effectors into immune cells, altering cell signaling. Our study elucidates how one of these effectors, YopO, blocks phagocytosis. We demonstrate using different phagocytic models that YopO specifically blocks Rac-dependent Fcgamma receptor internalization pathway but not complement receptor 3-dependent uptake, which is controlled by Rho activity.
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- Parenteral Neisseria meningitidis serogroup B (MenB) vaccination may change natural mucosal immunity in young adults, although its effects on mucosal T cell proliferation were minimal.
- The study involved immunizing healthy volunteers and comparing results of T cell immunity and cytokine production with unvaccinated controls.
- Findings showed that while systemic T cell immunity increased significantly post-vaccination, mucosal T cell responses became less biased toward Th1, indicating a selective reprogramming of existing immunity rather than a straightforward enhancement.
Background: Human papillomavirus (HPV) is known to infect the epithelium of the upper aerodigestive tract; however, major questions regarding prevalence and persistence of infection, and their relation to local immune response, remain unanswered.
Objectives: To evaluate the tonsil T cell immune response to HPV and compare this to the frequency of detectable virus at this site.
Study Design: A cross-sectional study of cancer-free adults undergoing routine tonsillectomy.
Neisseria meningitidis is commonly carried asymptomatically in the upper respiratory tract and only occasionally invades the bloodstream and meninges to cause disease. Naturally acquired immunity appears protective but the nature of the cellular immune response within the mucosa is uncertain. We show that following in vitro stimulation with N.
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