Publications by authors named "Elea Darras"
Article Synopsis
- CD8 T cells are crucial for the immune response against infections and tumors, and their proliferation is stimulated by dendritic cells (DCs).
- This study reveals that products released from thapsigargin-stimulated mast cells impair the ability of DCs to induce CD8 T-cell proliferation and Th1 cytokine production.
- While thapsLAD2-matured DCs show some maturation markers, they produce no detectable TNF or IL-12 and are less effective than R848-matured DCs in promoting CD8 T-cell proliferation, highlighting a new way mast cells can regulate immune responses.
The immune checkpoint inhibitors have revolutionized cancer immunotherapy. These inhibitors are game changers in many cancers and for many patients, sometimes show unprecedented therapeutic efficacy. However, their therapeutic efficacy is largely limited in many solid tumors where the tumor-controlled immune microenvironment prevents the immune system from efficiently reaching, recognizing, and eliminating cancer cells.
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