Publications by authors named "Elcin E Umur"
Increased iron and oxidative stress are separately related to cognitive decline in elderly.
Geriatr Gerontol Int
October 2011
Article Synopsis
- The study investigates how body iron levels and oxidative stress relate to cognitive function in elderly nursing home residents, measuring their cognitive status using the Mini-Mental State Examination (MMSE).
- Among 87 participants, those with cognitive dysfunction had higher serum iron and malondialdehyde (MDA) levels, but lower glutathione peroxidase (GSH-Px) enzyme activity compared to their cognitively normal counterparts.
- The findings suggest that elevated iron markers and oxidative stress are linked to cognitive dysfunction, yet no direct correlation was found between iron deposition and oxidative stress, indicating a need for further research on potential treatments.
We aimed to investigate the rate of MEFV, the gene mutated in familial Mediterranean fever, mutations in patients with myeloid neoplasm and to determine if known mutations of MEFV cause a tendency for myeloid neoplasms. The frequency of the five most common MEFV gene mutations (M694V, M680I, V726A, E148Q and M694I) was determined in 26 patients with myeloid neoplasm. We identified 1 homozygous (E148Q/E148Q), 1 compound heterozygous (M694V/E148Q) and 5 heterozygous MEFV gene mutations; none had their own and/or family history compatible with familial Mediterranean fever.
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