Publications by authors named "Elcimar de S Barros"
Pharmaceuticals (Basel)
November 2024
Article Synopsis
- - The study involved screening around 2.5 million compounds from various databases to identify potential inhibitors of a chimeric tyrosine kinase, focusing on their antiproliferative activity and pharmacokinetic properties.
- - Nine compounds were identified as having desirable ADME/Tox properties, with their biological activity predictions indicating that they could be effective protein kinase inhibitors, showing varied activity percentages.
- - Two promising compounds, LMQC01 and LMQC04, demonstrated strong molecular docking results and stability in simulations, suggesting they have good potential for inhibiting the enzyme function of the target kinase and are easy to synthesize.
