Snake Venom and a Phospholipase A Isolated from This Venom Elicit Macrophages to Form Lipid Droplets and Synthesize Inflammatory Lipid Mediators.

Viper snake (Cdr) is a subspecies found in northern area of Brazil. Among the snakes of genus subspecies, the venom of Cdr presents highest level of crotoxin, which is the major component of snake venoms, formed by two subunits (crotapotin and a phospholipase A named CBr) and presents potent neurotoxic activity. Curiously, the venom of (CdrV) is better neutralized by antibothropic than by anticrotalic serum, strongly suggesting that this venom has similarities with venom of genus snakes with regard to the ability to induce inflammation.