Hyper-N-glycosylated SEL1L3 as auto-antigenic B-cell receptor target of primary vitreoretinal lymphomas.

Primary vitreoretinal lymphoma (PVRL) is a rare subtype of DLBCL and can progress into primary central nervous system lymphoma (PCNSL). To investigate the role of chronic antigenic stimulation in PVRL, we cloned and expressed B-cell receptors (BCR) from PVRL patients and tested for binding against human auto-antigens. SEL1L3, a protein with multiple glycosylation sites, was identified as the BCR target in 3/20 PVRL cases.

Profiles in Criminal Psychopathology: A Multiple Case Report Study of the Factor.

(1) Background: The one general psychopathology ( Factor) theory asserts that a superordinate dimensional construct encompasses underlying forms of psychopathology, but the theory has limited empirical linkages to criminology. (2) Methods: We utilized case reports from 12 male offenders selected from a federal jurisdiction in the central United States who were in the 99th percentile on a composite indicator of psychopathology to advance a qualitative study of the Factor. (3) Results: Clients experienced frequent and often pathological traumatic experiences and exhibited exceedingly early onset of conduct problems usually during the preschool period.

The p factor, crime, and criminal justice: A criminological study of Caspi et al.'s general psychopathology general theory.

The general psychopathology general theory or p Factor is an influential theoretical development in the social and behavioral sciences, but has yet to gain traction in criminology and criminal justice. Drawing on data from a sample of 1722 federal pretrial defendants, we created a 22-item composite indicator or additive index of the p Factor containing externalizing, internalizing, substance use, paraphilic, and forensic indicators. Negative binomial regression models found that age, sex, and diverse forms of trauma exposure are associated with higher p Factor scores.

Who Are the Compliant Correctional Clients? New Evidence on Protective Factors among Federal Supervised Releases.

Protective factors facilitate success on community supervision, but relatively little is known about correctional clients who are highly compliant particularly in the federal system. Drawing on a near population of federal clients on supervised release in the Midwestern United States, the current study examined variables associated with compliant supervision status. One day on supervision contributed to a 1% reduction in the logged odds of supervision compliance.

The dark figure of sexual offending: A replication and extension.

Studies of the dark figure of sexual offending using federal correctional clients reported significant evidence of previously unknown or hidden sexual violence, often among clients with no official criminal history. Unfortunately, research has produced variable estimates of how large the dark figure is. The current study sought to replicate recent studies of federal sexual offenders about the dark figure of sexual offending.

Childhood sexual abuse is significantly associated with subsequent sexual offending: New evidence among federal correctional clients.

Background: Adverse childhood experiences are associated with multiple negative behavioral outcomes and childhood sexual abuse (CSA) is particularly damaging. There is controversial evidence that CSA has a specialized effect on subsequent sexual offending.

Objective: The current study tested the hypothesis that CSA is associated with sexual offending.

The etiology of antisocial personality disorder: The differential roles of adverse childhood experiences and childhood psychopathology.

Antisocial Personality Disorder (ASPD) is a severe personality disorder with robust associations with crime and violence, but its precise etiology is unknown. Drawing on near-population of federal correctional clients in the Midwestern United States, the current study examined antecedent background factors spanning adverse childhood experiences and childhood psychopathology. Greater adverse childhood experiences were associated with ASPD diagnosis with physical abuse showing associations with ASPD symptoms and sexual abuse with lifetime diagnosis for ASPD.

Do behavioral disorders render gang status spurious? New insights.

In community and correctional settings, gang status is a robust predictor of offending, unfortunately relatively few studies have considered behavioral disorders of offenders and whether these disorders mediate the gang-offending relationship. Drawing on a near population of correctional clients on federal supervised release, negative binomial regression and ROC-AUC models found that gang variables were rendered insignificant or were generally weak classifiers of severe offending once behavioral disorders were specified. The only exception was security threat group status that was robustly associated with prison misconduct.

De Novo Advanced Adult-Onset Offending: New Evidence from a Population of Federal Correctional Clients.

Adult antisocial behavior is almost always predated by delinquency during childhood or adolescence; however, there is also evidence of adult-onset criminal offending. This study examined this controversial subgroup of offenders using self-reported and official data from a total population of federal correctional clients selected from the Midwestern United States. Difference of means t-tests, chi-square tests, and logistic regression models found that 11.

PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells.

Mammalian Par1 is a family of serine/threonine kinases comprised of four homologous isoforms that have been associated with tumor suppression and differentiation of epithelial and neuronal cells, yet little is known about their cellular functions. In polarizing kidney epithelial (Madin-Darby canine kidney [MDCK]) cells, the Par1 isoform Par1b/MARK2/EMK1 promotes the E-cadherin-dependent compaction, columnarization, and cytoskeletal organization characteristic of differentiated columnar epithelia. Here, we identify two functions of Par1b that likely contribute to its role as a tumor suppressor in epithelial cells.

The yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machinery.

Kin1 and Kin2 are Saccharomyces cerevisiae counterparts of Par-1, the Caenorhabditis elegans kinase essential for the establishment of polarity in the one cell embryo. Here, we present evidence for a novel link between Kin1, Kin2, and the secretory machinery of the budding yeast. We isolated KIN1 and KIN2 as suppressors of a mutant form of Rho3, a Rho-GTPase acting in polarized trafficking.

A Prospective Longitudinal Study of Phonological Development in Late Talkers.

Purpose: This study involved prospective longitudinal data on 5 late talkers to provide information about the course of phonological development in order to identify possible predictors of delayed versus deviant development.

Method: Five children (3 boys, 2 girls) were identified as late talkers and divided into a younger group and an older group. Each child was followed monthly for 10 to 12 months (22-33 months for the younger group and 30-42 months for the older group).

Patterns of sound change in children with phonological disorders.

This paper presents longitudinal data that provide insight into the phonological learning of five children. These children were superficially similar in that all presented with errors affecting production of [s]; however, it will be argued that each child possessed a phonological system that was unique in certain ways. Production of [s]was established with each participant using a motoric training approach, and generalization was assessed over a 3-4-month period using a 50-item probe.

Facilitating [s] production in young children: an experimental evaluation of motoric and conceptual treatment approaches.

Eighteen phonologically disordered children were assigned to one of two experimental treatment programmes. Half of the children received a motoric treatment, which focused on establishing sound production in isolation, words, and phrases. The remaining children received a conceptual treatment, which sought to establish the phonemic nature of /s/ without providing motor practice.

Enhancing stimulability: a treatment program.

Recent research on stimulability and generalization suggests that treatment of nonstimulable sounds results in maximum treatment gains (Powell, Elbert, & Dinnsen, 1991). It has also been suggested, however, that nonstimulable sounds are more difficult to teach, especially to young children with very small phonetic inventories. In this article, we describe a treatment program designed to increase the size of the phonetic inventory by "teaching" stimulability.

Spectral analysis of target-appropriate /t/ and /k/ produced by phonologically disordered and normally articulating children.

Previous research (Forrest, Weismer, Hodge, Dinnsen and Elbert, 1990) has shown that some phonologically disordered children differentially mark seemingly homophonous phonemes; however, the resulting contrast may be spectrally distinct from that produced by normally articulating children of the same age. In the present investigation possible sources for these differences between normally articulating and phonologically disordered children's productions of target-appropriate phonemes were pursued. Spectral characteristics of seemingly correct productions of /t/ and /k/ in word-initial position were analysed for four normally articulating and seven phonologically disordered children to assess the effect of recency of acquisition, depth of knowledge of the contrast and/or the effect of a phonological disorder on accuracy and variability of production.

Stimulability as a factor in the phonological generalization of misarticulating preschool children.

The relationship among six functionally misarticulating preschool children's phoneme-specific stimulability skills, the choice of treatment targets (i.e., stimulable or nonstimulable sounds), and generalization of correct sound production was explored in this prospective study.

Toward a technology of generalization: how many exemplars are sufficient?

This descriptive study examined the number of minimal-word-pair exemplars necessary for 19 phonologically impaired children to meet a generalization criterion. For 59% of the test cases, three exemplars were sufficient for generalization to occur. Five exemplars were sufficient in 21% of the test cases, and it was necessary to teach 10 different exemplars in 14% of the test cases.

Generalization to conversational speech.

Although changes in children's phonological systems due to treatment have been documented in single-word testing, changes in conversational speech are less well known. Single-word and conversation samples were analyzed for 10 phonologically disordered children, before and after treatment and 3 months later. Results suggest that for most of the children, there were system changes in both single words and in conversational speech.

Listeners' familiarity and perception of an idiosyncratic phonologic pattern.

Idiosyncratic production of [l] for target /j/ (for example, production of the word "less" for "yes") was observed in a phonologically impaired preschooler. Recordings of his apparently homonymous productions of minimal pairs contrasting /j/ and /l/ were presented in random order to the child's mother and to five adult listeners who were unfamiliar with the child. No difference was seen across the listeners in their ability to identify target /l/ words.

Some constraints on functionally disordered phonologies: phonetic inventories and phonotactics.

The phonological systems of 40 functional misarticulators, ages 40 to 80 months were examined in terms of the nature and variation of phonetic inventories and phonotactic constraints. It was found that these properties of disordered systems were governed by severe constraints that yielded a typological characterization of such systems along with associated implicational laws. The principles governing disordered systems were also found to parallel closely the principles governing normal first language acquisition.

Evaluating the treatment effect of repeated probes.

This study investigated the effect of the administration of frequent and infrequent probe lists on generalization to novel stimuli. Four subjects with multiple functional articulation errors were taught to produce two different sounds, and generalization was measured on three probe lists. Two of the probe lists (one for each sound) were administered infrequently, and the third probe list (for one sound) was presented at each treatment session.