Publications by authors named "Elarbi Goufa"
Article Synopsis
- Acute coronary syndrome (ACS) continues to be a major health challenge globally, even with improved treatment options.
- This study evaluated the impact of empagliflozin, an SGLT2 inhibitor typically used for managing type 2 diabetes, on heart function in ACS patients by analyzing data from four randomized controlled trials with a total of 701 participants.
- Results showed that empagliflozin significantly improved certain left cardiac parameters, like reducing left ventricular end-systolic volume and mass, although it did not significantly change left ventricular ejection fraction or end-diastolic volume, indicating its potential as a complementary treatment in ACS cases.
Article Synopsis
- Rett syndrome is a rare neurodevelopmental disorder primarily affecting females, caused by mutations in the MECP2 gene on the X chromosome.
- Trofinetide is a newly developed drug aimed at providing neuroprotective effects, and this meta-analysis assesses its efficacy and safety compared to placebo in treating RTT.
- The results from three randomized controlled trials involving 325 patients indicate that Trofinetide significantly improves symptoms without severe side effects, making it a promising treatment option for RTT.
Objectives: Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disease that can overlap with pregnancy, but little is known about its clinical characteristics, course, and outcomes in this context. This systematic review aimed to synthesize the current evidence on ALS overlapping with pregnancy.
Methods: We comprehensively searched four databases on February 2, 2023, to identify case studies reporting cases of ALS overlapping with pregnancy.