Thyroseq V3 Molecular Profiling for Tailoring the Surgical Management of Hürthle Cell Neoplasms.

Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV.

Vascular and capsular pseudoinvasion in thyroid neoplasms.

The diagnosis of follicular carcinoma of the thyroid requires the identification of capsular and/or vascular invasion, with the exception of distant metastases. However, several artifacts may mimic both vascular and capsular invasion. This article presents two cases of pseudo invasion in encapsulated follicular neoplasms.

Fine-needle aspiration in the evaluation of nucleated red blood cells in the human placenta.

Objective: The purpose of this study was to evaluate the correlation between placental and umbilical cord nucleated red blood cell counts.

Study Design: Eighty placentas and their matched umbilical cord blood samples were collected prospectively immediately after delivery. In vitro fine-needle aspiration biopsy specimens were used to obtain placental tissue samples.

Polymorphous hemangioendothelioma of the neck.

Polymorphous hemangioendotheliomas are rare, low-grade borderline malignant vascular tumors of endothelial cell origin. To the best of our knowledge (MEDLINE 1966-2002), there have been nine cases of polymorphous hemangioendothelioma reported in the English literature. Most of the initial patients reported were men, but we present the third case in a woman.