Associations between IL-1β, IL-6, and TNFα polymorphisms and longitudinal trajectories of cognitive function in non-demented older adults.

Inflammation is implicated in Alzheimer's disease (AD), and specific single nucleotide polymorphisms (SNPs) in inflammatory cytokine genes are associated with increased AD risk. Whether the same polymorphisms also predict domain-specific cognitive change in cognitively healthy older adults is unclear. Specific SNPs in three cytokine genes, IL-1β (rs16944), IL-6 (rs1800795), and TNFα (rs1800629) were assessed for association with longitudinal trajectories spanning up to 16 years of global cognitive function, episodic memory, attention and working memory, and executive function in a sample of 324 non-demented older adults.

The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults' social networks.

Interferon-γ (IFN-γ), an inflammatory biomarker that promotes antiviral immunity, may be a prerequisite for sociability. IFN-γ production in older adulthood is driven by late-differentiated CD8 T cells, particularly CD28and CD57 subsets, which increase with age, reduce immune response, and increase chronic disease risk. The present study investigated the relationship between late-differentiated T cells (LDTC) and sociability in a longitudinal study of healthy aging.

Sleep Variability and Inflammation in Midlife and Older Women.

Objective: Shorter sleep duration and more sleep disturbances, in addition to greater night-to-night fluctuations in sleep (intraindividual variability; IIV), have been associated with elevated inflammation. However, these associations were only at the between-person level. The current study examined the within-person relationship between mean levels and IIV of sleep duration and sleep disturbances and C-reactive protein (CRP) in healthy, aging women.

Repetitive thought, cognition, and systemic inflammation in the midlife in the United States study.

Objective: Poor cognition increases risk for negative health outcomes, and this may be explained by associations with systemic inflammation. Previously, amount of repetitive thought (Total RT) interacted with IQ to predict interleukin-6 (IL-6) in older adults. This study continued the investigation of repetitive thought (RT) as an element involved in the effect of cognition on inflammation.

Discrimination and health: The mediating role of daily stress processes.

Objective: Exposure to discrimination is consistently linked with worse physical and mental health outcomes. One potential reason is that discriminatory experiences shape the way people interpret and affectively react to daily stressful events which in turn impacts health. The current study examined the role of these two daily psychological stress processes as a pathway linking the longitudinal association between perceived discrimination and health outcomes.

A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect.

We conducted a preregistered multilaboratory project ( = 36; = 3,531) to assess the size and robustness of ego-depletion effects using a novel replication method, termed the . Each laboratory implemented one of two procedures that was intended to manipulate self-control and tested performance on a subsequent measure of self-control. Confirmatory tests found a nonsignificant result ( = 0.

Exposure and reactivity to repetitive thought in the neuroticism-distress relationship.

Introduction: Distress has been assumed to result from exposure to repetitive thought (RT). However, if RT is viewed as internally generated stressors, both exposure and affective reactivity to RT could play roles in generating distress.

Methods: Three studies (young adults, N=99; midlife women, N=111; older adults, N=159) assessed exposure and reactivity to daily RT and tested whether neuroticism was related to individual differences in both exposure and affective reactivity.

Correlates of Poor Sleep and Subsequent Risk of Misdiagnosis in College Students Presenting with Cognitive Complaints.

Objectives: To examine the relationships of poor sleep to both subjective and objective cognitive functioning, attention deficit hyperactivity disorder (ADHD) and sluggish cognitive tempo (SCT) symptoms, and mental health variables in college students, controlling for noncredible symptom reporting and noncredible performance.

Methods: 99 undergraduate students (Mage = 19.9, SD = 1.