Publications by authors named "Elana Fine"
Article Synopsis
- Motion-induced anxiety and agoraphobia are more common in patients with vestibular migraine compared to those without vertigo, highlighting the relevance of neuropeptides like CGRP in understanding these conditions.
- The study investigated how systemic CGRP and off-vertical axis rotation (OVAR) influenced anxiety-like behavior and balance in male and female C57BL/6J mice, revealing that only the combination of CGRP and OVAR increased anxiety indices.
- Results indicate that CGRP affects balance performance based on challenge type, suggesting that future research could explore whether CGRP receptor antagonists can alleviate both migraine symptoms and associated anxiety in mice.
Unlabelled: Motion-induced anxiety and agoraphobia are more frequent symptoms in patients with vestibular migraine than migraine without vertigo. The neuropeptide calcitonin gene-related peptide (CGRP) is a therapeutic target for migraine and vestibular migraine, but the link between motion hypersensitivity, anxiety, and CGRP is relatively unexplored, especially in preclinical mouse models. To further examine this link, we tested the effects of systemic CGRP and off-vertical axis rotation (OVAR) on elevated plus maze (EPM) and rotarod performance in male and female C57BL/6J mice.
View Article and Find Full Text PDF