Publications by authors named "Elaiyaraja Subramanian"
Article Synopsis
- Salamander limb regeneration involves the formation of a blastema, where stump cells undergo dedifferentiation to contribute to regrowth.
- A mechanism of protein synthesis inhibition during this process has been identified, and relieving this inhibition boosts cell cycling and speeds up regeneration.
- The study highlights miR-10b-5p’s role in regulating ribosomal mRNA and protein synthesis, showing that its downregulation is essential for effective limb regeneration in newts.
Salamander limb regeneration is an accurate process which gives rise exclusively to the missing structures, irrespective of the amputation level. This suggests that cells in the stump have an awareness of their spatial location, a property termed positional identity. Little is known about how positional identity is encoded, in salamanders or other biological systems.
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