Validity evidence for endoscopic ultrasound competency assessment tools: Systematic review.

Competent endoscopic ultrasound (EUS) performance requires a combination of technical, cognitive, and non-technical skills. Direct observation assessment tools can be employed to enhance learning and ascertain clinical competence; however, there is a need to systematically evaluate validity evidence supporting their use. We aimed to evaluate the validity evidence of competency assessment tools for EUS and examine their educational utility.

Intensionality is more cognitively demanding than false belief in adults: evidence from a non-inferential sentence-reading task.

Children are said to understand false belief if they can appreciate an agent's wrong description of an object as a result of misinformation, and intensionality if they can appreciate and switch between alternative descriptions from different epistemic viewpoints. Most previous studies have investigated the developmental trajectories of these capacities in the age range from 3 to 10 years aiming to discern their conceptual nature. The present research examines whether intensionality incurs lower performance accuracies and longer response times than false belief in adults, using a task in which participants read sentences that explicitly state an agent's beliefs.

Measures of individual differences in adult theory of mind: A systematic review.

Theory of mind (ToM), the ability to understand and reason about mental states, has been extensively studied in young children and clinical populations. A growing interest in examining ToM in adults has emerged over the past two decades, but the extent to which existing measures are suitable for studying adults, especially in detecting individual differences, remains understudied. In this systematic review of 273 studies, 75 measures used to investigate individual differences in adults' ToM were identified.

Flood resilience loci and interact in seedlings established underwater.

Crops with resilience to multiple climatic stresses are essential for increased yield stability. Here, we evaluate the interaction between two loci associated with flooding survival in rice ( L.).

After The Deluge: Plant Revival Post-Flooding.

Increasing flooding events have detrimentally impacted food security amid a growing global population. Complete submergence of plants represents the most severe flooding stress and studies have identified underwater responses to low oxygen and light availability. However, knowledge on plant responses during the post-submergence phase is limited.

A stress recovery signaling network for enhanced flooding tolerance in .

Abiotic stresses in plants are often transient, and the recovery phase following stress removal is critical. Flooding, a major abiotic stress that negatively impacts plant biodiversity and agriculture, is a sequential stress where tolerance is strongly dependent on viability underwater and during the postflooding period. Here we show that in accessions (Bay-0 and Lp2-6), different rates of submergence recovery correlate with submergence tolerance and fecundity.

Signal Dynamics and Interactions during Flooding Stress.

Flooding is detrimental for nearly all higher plants, including crops. The compound stress elicited by slow gas exchange and low light levels under water is responsible for both a carbon and an energy crisis ultimately leading to plant death. The endogenous concentrations of four gaseous compounds, oxygen, carbon dioxide, ethylene, and nitric oxide, change during the submergence of plant organs in water.

Reliability of EUS indices to detect inflammation in ulcerative colitis.

Background And Aims: EUS is a potentially useful modality to assess severity of inflammation in ulcerative colitis (UC). We assessed the reliability of existing EUS indices and correlated them with endoscopic and histologic scores.

Methods: Four blinded endosonographers assessed 58 endoscopic and EUS videos in triplicate, from patients with UC.

Regional differences in use of endoscopic ultrasonography in Ontario: a population-based retrospective cohort study.

Background: Endoscopic ultrasonography is a safe and accurate modality for evaluating and managing hepatobiliary and gastrointestinal conditions (malignant and nonmalignant); its use is increasing. The aim of this study was to describe regional trends in the use of endoscopic ultrasonography in Ontario.

Methods: We conducted a population-based retrospective cohort study using health administrative databases.

The submergence tolerance gene SUB1A delays leaf senescence under prolonged darkness through hormonal regulation in rice.

Leaf senescence is a natural age-dependent process that is induced prematurely by various environmental stresses. Typical alterations during leaf senescence include breakdown of chlorophyll, a shift to catabolism of energy reserves, and induction of senescence-associated genes, all of which can occur during submergence, drought, and constant darkness. Here, we evaluated the influence of the submergence tolerance regulator, SUBMERGENCE1A (SUB1A), in the acclimation responses during leaf senescence caused by prolonged darkness in rice (Oryza sativa).

The submergence tolerance regulator SUB1A mediates crosstalk between submergence and drought tolerance in rice.

Submergence and drought are major constraints to rice (Oryza sativa) production in rain-fed farmlands, both of which can occur sequentially during a single crop cycle. SUB1A, an ERF transcription factor found in limited rice accessions, dampens ethylene production and gibberellic acid responsiveness during submergence, economizing carbohydrate reserves and significantly prolonging endurance. Here, we evaluated the functional role of SUB1A in acclimation to dehydration.

Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.

Emerging data have indicated that hepatitis C virus (HCV) subverts the host antiviral response to ensure its persistence. We previously demonstrated that HCV protein expression suppresses type I interferon (IFN) signaling by leading to the reduction of phosphorylated STAT1 (P-STAT1). We also demonstrated that HCV core protein directly bound to STAT1.

Ramipril-associated hepatotoxicity.

Context: Angiotensin-converting enzyme inhibitors are prescribed for many cardiovascular and renal diseases. Adverse hepatic events, especially cholestasis, have rarely been reported with captopril, enalapril, lisinopril, and fosinopril. To date, hepatic injury associated with ramipril has not been reported.

Monitoring adverse drug reactions to sulfonamide antibiotics in human immunodeficiency virus-infected individuals.

Patients infected with the human immunodeficiency virus (HIV) are at higher risk for adverse drug reactions from trimethoprim-sulfamethoxazole (TMP-SMX) than the HIV-negative population. Studying the HIV-positive population the authors aimed to validate the predictive and diagnostic value of the lymphocyte toxicity assay (LTA) for adverse drug reactions. Patient lymphocytes were analyzed for toxicity to SMX and TMP.