Exploring the prenatal experience of women with intellectual and developmental disabilities: In a southeastern Ontario family health team.

Objective: To identify psychosocial challenges facing pregnant women with intellectual and developmental disabilities (IDD) using retrospective, routinely collected electronic medical record data.

Design: A retrospective qualitative study using narratives and supporting documents found in the electronic medical record of an academic family health team (FHT).

Setting: Academic FHT in southeastern Ontario.

Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.

Activation-induced cytidine deaminase (AID) is essential for class-switch recombination (CSR) and somatic hypermutation (SHM) of Ig genes. The AID C terminus is required for CSR, but not for S-region DNA double-strand breaks (DSBs) during CSR, and it is not required for SHM. AID lacking the C terminus (ΔAID) is a dominant negative (DN) mutant, because human patients heterozygous for this mutant fail to undergo CSR.