Effects of soy isoflavones on the uterus and urethra of ovariectomized rats.

Objective: To evaluate the effect of soy isoflavone extract (SIE) on the uterus and urethra of castrated female rats.

Methods: Ovariectomized adult virgin Wistar rats (n = 45) received, for 30 days: placebo (GI); SIE from day 5 of castration (GII); or day 28 of castration (GIII). A standardized SIE was administered by gavage at 125 microg genistein/g body weight/day, with a soy-free diet.