Publications by authors named "Elaine Schalk"
Front Immunol
August 2024
Article Synopsis
- Scientists studied a sensor called STING that helps the body respond to stress and viruses, even when there isn’t typical DNA present.*
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- They found that a special stress response in cells called the unfolded protein response (UPR) can activate STING and help create a certain type of DNA that triggers defense responses.*
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- They discovered that two specific pathways in the UPR, called IRE1 and PERK, play important roles in releasing this DNA and activating immune responses against viruses.*
Article Synopsis
- - The study investigates how endoplasmic reticulum (ER) stress activates the STING pathway, which is involved in immune responses, even in the absence of typical DNA or cyclic di-nucleotide stimuli.
- - Researchers found that the induction of IFN-β (an immune response protein) during ER stress requires both STING and cyclic GMP-AMP synthase (cGAS), involving the release of mitochondrial DNA into the cytoplasm.
- - The study identifies that specific ER stress pathways, particularly the IRE1-XBP1 and PERK pathways, are crucial for generating cytosolic dsDNA and modulating IFN-β production during responses to both viral infections and ER stress.
