Publications by authors named "Elaine Ruiz"
An Investigation of Diversity in Childhood and Adolescent Antidepressant Studies: A Systematic Review.
J Child Adolesc Psychopharmacol
June 2023
Childhood mental illness is an ongoing public health crisis which is accompanied by an increase in antidepressant (i.e., serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors) use in children.
View Article and Find Full Text PDFLeptin is important in regulating energy homeostasis. Severe lipodystrophy is associated with leptin deficiency and insulin resistance, hypertriglyceridemia, and hepatic steatosis. Leptin deficiency is also associated with abnormalities of the pituitary hormones in rodent models and patients with congenital absence of leptin.
View Article and Find Full Text PDFArticle Synopsis
- Leptin is a hormone regulating energy balance, and its deficiency in severe lipodystrophy leads to issues like diabetes and high triglycerides.
- Nine female patients with low leptin levels received recombinant leptin injections for four months, resulting in significantly higher serum leptin levels and improved health metrics.
- The treatment led to notable reductions in blood sugar levels, triglycerides, liver volume, and even decreased caloric intake, indicating that leptin therapy is beneficial for addressing metabolic problems in lipodystrophy.