Publications by authors named "Elaine Rodrigues Mello"
Article Synopsis
- Two alkaloids, pterogynine (PGN) and pterogynidine (PGD), from the Brazilian plant Pterogyne nitens were found to induce programmed cell death (apoptosis) in human breast cancer cells.
- The study involved testing these compounds on a specific human breast cancer cell line (ZR-7531) with varying concentrations (0.25-10 mM) and analyzing the results using different assays, including Hoechst and annexin V.
- The findings highlight that while both PGN and PGD effectively kill cancer cells in vitro, the Hoechst assay effectively distinguishes between late apoptosis and necrosis, which the annexin V assay could not.
ABH and Lewis antigen expression has been associated with cancer development and prognosis, tumor differentiation, and metastasis. Considering that invasive ductal breast carcinoma (IDC) presents multiple molecular alterations, the aim of the present study was to determine whether the polymorphism of ABO, Lewis, and Secretor genes, as well as ABO phenotyping, could be associated with tumor differentiation and lymph nodes metastasis. Seventy-six women with IDC and 78 healthy female blood donors were submitted to ABO phenotyping/genotyping and Lewis and Secretor genotyping.
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