Cellular toxicology and mechanism of the response to silver-based nanoparticle exposure in Ewing's sarcoma cells.

Ewing's sarcoma is the most aggressive connective tissue tumor, mainly affecting children and adolescents; the 5 year survival rate is only 50%. Current treatments have poor effectiveness, and more efficient treatments are being sought. Silver-based nanoparticles, such as silver chloride nanoparticles (AgCl-NPs) and silver/silver chloride (Ag/AgCl-NPs) nanoparticles, can be biologically produced and can release Ag ions into solution; however, their antitumor activity has been minimally investigated.