Publications by authors named "Elaine Boydston"
Objective: The objective was to determine the optimal cell saver device settings (infusion rate and wash rate) at which hematocrit is preserved and potassium and lactate are removed from banked red blood cells (RBC).
Design: Red cells were washed using the Cobe BRAT 2 Autologous Blood Recovery Unit and sampled for electrolyte composition and hematocrit pre- and postwash.
Setting: This was a single-center study.
Article Synopsis
- Plasmalemmal repair is crucial for the survival of damaged eukaryotic cells, and this process involves calcium (Ca2+) influx, which activates calpain and various membrane fusion proteins, while also triggering competing apoptotic pathways.
- B104 hippocampal cells show that those with neurites closer to the cell body seal their membranes at a slower rate compared to those further away, but the presence of cAMP analogs can enhance and even initiate this sealing process without needing Ca2+ influx.
- Research suggests that multiple pathways, including Ca2+-dependent mechanisms and cAMP activation, are involved in plasmalemmal sealing and that understanding these pathways could lead to new treatments for nerve injuries and neurodegenerative diseases
Article Synopsis
- Researchers found that polyethylene glycol (PEG) can quickly restore axon integrity in severed rat nerves, enhancing both physiological functionality and motor behavior.
- The study demonstrated that PEG-fusion led to improved conduction in damaged axons and quicker recovery of hindlimb motor skills in rats compared to untreated groups.
- Behavioral assessments revealed that early tests (like the foot fault test) showed significant recovery in the first few days post-surgery, while longer-term tests (like the Sciatic Functional Index) highlighted improved motor control over several weeks.*