Publications by authors named "Elaheh Ataollahi"
Leishmaniasis is a parasitic disease that is commonly found in tropical and sub-tropical regions. Currently, there is no protective antileishmanial vaccine, and the available clinical drugs have serious side effects. On the other hand, due to the emergence of multidrug-resistant strains of the causative pathogens, the study and design of novel antileishmanial agents is urgently needed.
View Article and Find Full Text PDFDPP4 inhibitors can control glucose homeostasis by increasing the level of GLP-1 incretins hormone due to dipeptidase mimicking. Despite the potent effects of DPP4 inhibitors, these compounds cause unwanted toxicity attributable to their effect on other enzymes. As a result, it seems essential to find novel and DPP4 selective compounds.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on designing and synthesizing two series of novel 1,4-benzothiazine-3-one derivatives as potential anti-convulsant agents, confirmed through various spectroscopy methods.
- The anti-convulsant effects were tested on mice using a specific seizure-inducing model, with compound 4h showing promising results.
- Computational studies, including molecular dynamics simulations and DFT analysis, supported the biological activity of the compounds, indicating that 4h has greater activity compared to 4c, while also examining their ADMET properties for optimal in-vivo performance.
Background: Azoles are the famous and widespread scaffold in the pharmaceutical industry due to their wide range of activities, high efficacy, good tolerability, and oral availability. Furthermore, azole derivatives have attracted attention as potent antimicrobial agents.
Introduction: The purpose of this review is to provide an overview of pharmacological aspects of the main scaffolds of azoles, including imidazole, benzimidazole, triazole, and tetrazole, which possess antimicrobial activity, reported from 2016 to 2020, as well as all of our publication in this field.