Exercise-activated hepatic autophagy combined with silymarin is associated with suppression of apoptosis in rats subjected to dexamethasone induced- fatty liver damage.

Aim: There is a need for effective treatments for non-alcoholic fatty liver disease (NAFLD) that are economically inexpensive, and have few side effects. The present study aimed to investigate exercise training and silymarin on hepatocyte death factors in rats with liver damage.

Methods: Forty-nine male Wistar rats were assigned to seven groups: sedentary control, fatty liver control (DEX), fatty liver + high-intensity interval training (HIIT), fatty liver + HIIT + silymarin (HIIT + SILY), fatty liver + continuous training (CT), fatty liver + CT + silymarin (CT + SILY), and fatty liver + silymarin (SILY).

Exercise training prevents high-fat diet-induced adipose tissue remodeling by promoting capillary density and macrophage polarization.

Aims: Increasing adipose tissue capillarization is beneficial to metabolic health. The present study examined the effects of continuous training (CT) and aerobic-interval training (AIT) coinciding with a high-fat diet (HFD) on capillary density, macrophage polarization in mesenteric (mAT) and subcutaneous (sAT) adipose tissue.

Main Methods: 48 male Wistar rats were divided into HFD and normal diet (ND) groups.

Short term resistance training enhanced plasma apoA-I and FABP4 levels in Streptozotocin-induced diabetic rats.

Background: Type 1 diabetes mellitus is associated with a high risk for early atherosclerotic complications. Altered lipids and lipoprotein metabolism in chronic diabetes mellitus is associated with pathogenesis of atherosclerosis and other cardiovascular diseases. The aim of this study was to investigate the effects of 4 weeks resistance training on plasma lipid profile, fatty acid binding protein (FABP) 4 and apolipoprotein (apo) A-I levels in type 1 diabetic rats.

Resistance training decreases serum inflammatory markers in diabetic rats.

Inflammation plays an important role in the genesis and progression of diabetes. The purpose of this study was to investigate the effect of resistance training on serum levels of some inflammatory markers associated with diabetes mellitus. Twenty-four male Wistar rats (290 ± 19 g) were randomly divided into three groups: non-diabetic control (non-DC), diabetic control (DC), and diabetic trained (DT).

The effect of exercise intensity on plasma and tissue acyl ghrelin concentrations in fasted rats.

Objective: This study was conducted to investigate the effect of exercise training and feeding status on plasma and tissue acyl ghrelin concentrations.

Materials And Methods: Thirty-two, eight-week-old male Wistar rats (185±5g) were randomly assigned to one of four groups: high intensity (HI: 34 m/min ~80-85% VO(2)max), moderate intensity (MI: 28 m/min ~70-75% VO(2)max), low intensity (LI: 20 m/min ~50-55% VO(2)max), and sedentary control (SED) groups. All experimental groups performed a 12-week exercise program consisting of treadmill running on a 0° slope for 1 h/day, 5 days/week at their respective training intensity.