Comparison of Accuracy in Calculation of Absorbed Dose to the Kidneys Following Radioligand Therapy with Lu-DKFZ-PSMA-617 by Two Different Background Correction Methods.

Background: To improve the accuracy of activity image quality, scatter correction is a critical method. The aim of this study is to compare the accuracy in calculation of absorbed dose to patients following radioligand therapy (RLT) with Lu-DKFZ-PSMA-617 by two different methods of background correction in the conjugate view method.

Materials And Methods: This study involved 10 patients.

Radiation Dose to Medical Staff from Administering Lu-PSMA-DKFZ-617 Therapy.

The number of radioligand therapy applications for metastatic castration-resistant prostate cancer has been continuously rising in most nuclear medicine departments in Iran, but to our knowledge, no one has studied the dose to staff who perform treatment procedures. The current study aimed to determine the external radiation dose received by staff who, using or not using a lead shield, treat patients with Lu-prostate-specific membrane antigen therapy. This study used a personal thermoluminescent digital survey meter to measure dose rates to staff at various distances from patients and determined the average time spent by staff at these distances.

Patient-Specific Dosimetry in Radioligand Therapy (RLT) for Metastatic Prostate Cancer Using Lu-DKFZ-PSMA-617.

Purpose: Lu-DKFZ-PSMA-617 is a promising treatment for patients with metastatic prostate cancer. Specific dosimetry for each patient is an important factor in planning the patient's treatment process. This study aimed to perform an image-based absorbed dose calculation for the treatment of metastatic prostate cancer with Lu-DKFZ-PSMA-617.

MicroRNA: A Potential Diagnosis for Male Infertility.

Male infertility is one of the major global health problems, in particular, in more than half of the affected men. Genetic factors are important for identifying men with idiopathic infertility along with semen analysis. Valid and useful information can be obtained through non-invasive molecular research.

Role of Oxidative Stress and Antioxidant Supplementation in Male Fertility.

Nearly 15% of couples experience infertility as a universal health issue. About 50% of infertility cases have been known to be associated with the male partner . Oxidative stress (OS) represents an imbalance in the level of reactive oxygen species (ROS) and anti-oxidants.