[Modifying action of oxytocin on the biological properties of the causative agents of anaerobic non-clostridial infection].

In a number of in vitro experiments the effect of oxytocin on the antilysozyme and anticomplemental activity of Propiobacterium propionicum, Bacteroides fragilis, Prevotella melaninogenica and Peptostreprtococcus anaerobius, isolated from patients with acute pyoinflammatory pleuropulmonary diseases, was studied. Antibiotic resistance dynamics of the infective agents under study to lincomycin, clindamycin, thienam, vancomycin was also detected. The inhibiting activity of oxytocin on the persistence properties of B.

[Microflora isolated in acute inflammatory pulmonary and pleural diseases].

The species composition and biological properties of microflora isolated from 42 patients with acute inflammatory pulmonary and pleural diseases were studied. A wide spectrum of aerobic and anaerobic microorganisms was detected. Infective agents causing severe course of the infectious process were found to have a high level of persistence properties.

[Microflora of the large intestine in patients with connective tissue dysplasia].

The specific features of intestinal aerobic and anaerobic intestinal microflora in children with nondifferentiated connective tissue dysplasia were under study. A high rate of dysbiotic disturbances was noted in patients with connective tissue dysplasia in comparison with healthy persons. Profound quantitative and qualitative changes in the biocenosis of the intestine were detected in patients with the pathology of the gastrointestinal tract as well as that of the locomotor system.

[Effect of bifidobacteria on the anti-lysozyme activity of enterobacteria].

The influence of the subinhibitory concentrations of bifidobacterial exometabolites on the capacity for inactivating lysozyme in pathogenic and opportunistic enterobacteria was determined. The supernatant of B. bifidum 1 suppressed antilysozyme activity (ALA) in most Klebsiella strains and in some pathogenic Escherichia coli strains, but increased ALA in some E.

[Modifying action of Saccharomyces boulardii on the biological properties of enterobacteria].

The influence of the exometabolites of the fungus S. boulardii, contained in the probiotic preparation "Enterol", on the biological properties of opportunistic and pathogenic enterobacteria of fecal microflora (inactivation of lysozyme, colicin production, hemolytic activity, antibiotic resistance) was studied. The study revealed that the supernatants of S.

[Colicinogenic activity of intestinal microflora as a sign of dysbacteriosis of the gastrointestinal tract].

Clinical and bacteriological studies have revealed that the production of colicin by Escherichia coli forming a part of intestinal microbiocenosis is related to the clinical manifestations of inflammatory diseases of the gastrointestinal tract. During the exacerbation of chronic inflammatory processes of the digestive system the proportion of colicin producing E. coli increases (more than 45%) in comparison with that of E.

[Anaerobic microflora of the female reproductive tract].

The microflora of the female reproductive tract is very diverse and plays an important role in both normal and pathological states. The data on the mechanisms of colonization resistance which involve the vaginal microbios (the production of H2O2, organic acids, bacteriocin-like substances, competition for adhesion sites) are presented. The data on the role of individual antagonistically active substances of anaerobic bacteria in suppressing gonococci, fungi, microorganisms, associated with bacterial vaginosis, etc.

[Antilysozyme activity of anaerobic bacteria from fecal microflora in man].

For the first time anaerobic bacteria of the fecal microflora in man have been found be capable of inactivating lysozyme. The presence of this antilysozyme sign has been noted in both Gram-positive anaerobes (Bifidobacterium, Propionibacterium, Eubacterium, Actinomyces israelii) and in Gram-negative anaerobes (Bacteroids, Prevotella melaninogenica). The expression of antilysozyme activity in the anaerobes under study has been determined.

[The photometric determination of the antilysozyme activity of microorganisms].

The method for the determination of the antilysozyme activity (ALA) of microorganisms, based on the photometric determination of the residual activity of enzyme with the use of Micrococcus lysodeikticus test culture after the incubation of the strain under test and lysozyme, is proposed. The new method enhances the reliability of the determination of the ALA of microorganisms due to an increase in the accuracy of the quantitative determination of ALA. The elimination of the stage of interaction between the growing bacterial culture and lysozyme and the presence of the antilysozyme factor in the supernatant fluid confirm the constructive and secretory character of antilysozyme activity.

[Effect of tomicide and the cell wall biopolymers of Streptococcus sp. Thom-1606 on mast cell degranulation].

The influence of tomicide and biopolymers obtained from the cell wall of Streptococcus sp. TOM-1606 on the degranulation of mast cells was studied. Among the biopolymers of the streptococcal cell-wall polysaccharide was shown to induce the highest destruction of mast cells (14.

[Action of tomicide on bacterial cells. The bacteriostatic, bactericidal and bacteriolytic properties of tomicide].

The effect of the minimum bacteriostatic and bactericidal concentrations of native and concentrated tomicid on Staphylococcus aureus, Streptococcus hemolyticus and Micrococcus was studied. It was shown that the bactericidal effect of tomicid was attained with the use of the doses 2-10 times higher than those required for the bacteriostatic effect. The minimum concentrations of tomicid effective against gram-positive cocci varied within the ranges described for the other biologically active substances of bacterial origin.