Publications by authors named "Elad Maor"

Background: Little is known about the recently emerging entity, heart failure with supranormal ejection fraction (HFsnEF).

Objective: To describe the clinical characteristics and outcome of HFsnEF, compared to HF with mildly reduced EF (HFmrEF) and HF with preserved EF (HFpEF) patients.

Design: A single center retrospective analysis.

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Background: Cardiovascular diseases are associated with higher cancer risk. However, their relationship with metastatic cancer, the primary determinant of cancer prognosis, has not been studied.

Objectives: This study aimed to determine the association between atherosclerotic cardiovascular disease and the presence of metastasis at the time of cancer diagnosis.

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The introduction of pulsed field ablation (PFA) in electrophysiology marks a significant advancement, promising efficacy comparable to thermal ablation methods while potentially providing safety advantages. Despite a generally favorable safety profile in human trials and postmarket registries, cautious evaluation of PFA's safety is essential. This review provides a comprehensive overview of key safety considerations as we discuss a myriad of considerations ranging from thermal effects, gaseous microbubble formation, muscle contractions, and proarrhythmia to procedural techniques.

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Article Synopsis
  • This study aimed to assess the relationship between flow measurements from left ventricular assist devices (LVADs) and invasive cardiac output measurements using different methods.
  • Researchers analyzed data from 102 LVAD patients, identifying significant discordance between methods, where 45% had differences when using indirect Fick and 48% with thermodilution compared to pump flow.
  • The findings suggested that while LVAD flow estimates correlate strongly with traditional cardiac output measures, particularly thermodilution, the correlation improves when low indirect Fick values are excluded.
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Transcatheter aortic valve replacement (TAVR) is indicated for severe aortic stenosis patients with a prohibitive surgical risk. However, its use has been expanding in recent years to include intermediate- and low-risk patients. Thus, registry data describing changes in patient characteristics and outcomes are needed.

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Background And Aims: Long-term data on atrial fibrillation (AF) impact on tricuspid regurgitation (TR) progression and its relation to pulmonary pressure are scant. We investigated this association in a study spanning over a decade.

Methods: Adults with echocardiographic evaluation before 2014, free of significant TR, were included.

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Background: The cardiovascular and metabolic benefits of physical activity have been studied at length, however, data on the association between physical fitness and progression to kidney disease is lacking. We aimed to identify the association between cardiorespiratory fitness and development of chronic kidney disease (CKD) among the healthy population.

Methods: We retrospectively investigated 11,579 healthy self-referred subjects who underwent annual medical screening.

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Background: Age and sex can be estimated using artificial intelligence on the basis of various sources. The aims of this study were to test whether convolutional neural networks could be trained to estimate age and predict sex using standard transthoracic echocardiography and to evaluate the prognostic implications.

Methods: The algorithm was trained on 76,342 patients, validated in 22,825 patients, and tested in 20,960 patients.

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Purpose: To evaluate the association of cardiorespiratory fitness with elevated intraocular pressure (IOP) in healthy adults.

Methods: In this cross-sectional study, we evaluated 17,990 asymptomatic self-referred adults free of diabetes or cardiovascular disease who were screened in a preventive healthcare setting. All subjects underwent measurement of IOP and completed a maximal exercise stress test according to the Bruce protocol.

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: Serum uric acid is an established cardiovascular risk factor. Higher serum uric acid levels are associated with overweight and obesity. We assessed whether non-interventional weight changes affect serum uric acid levels.

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Background: Cardiac amyloidosis (CA) is characterized by the extracellular deposition of misfolded protein in the heart. Precise identification of the amyloid type is often challenging, but critical, since the treatment and prognosis depend on the disease form and the type of deposited amyloid. Coexistence of clinical conditions such as old age, monoclonal gammopathy, chronic inflammation, or peripheral neuropathy in a patient with cardiomyopathy creates a differential diagnosis between the major types of CA: amyloidosis light chains (AL), amyloidosis transthyretin (ATTR) and amyloidosis A (AA).

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Background: The safety and impact of sodium glucose transporter 2 inhibitors (SGLT2-I) in patients with left ventricular assist devices (LVAD) are unknown.

Methods: A retrospective analysis of all consecutive patients who underwent LVAD Heart Mate 3 (HM3) implantation at a single medical center and received SGLT2-I therapy following surgery was conducted. LVAD parameters, medical therapy, laboratory tests, echocardiography, and right heart catheterization (RHC) study results were recorded and compared before and after initiation of SGLT2-I.

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Background: Obesity is associated with dyslipidemia, and weight loss can improve obese patients' lipid profile. Here, we assessed whether non-interventional weight changes are associated with alterations in lipid profile, particularly the triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C).

Methods: In this retrospective analysis of subjects referred to medical screening, body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), TG, and HDL-C levels were measured annually.

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Article Synopsis
  • Electroporation is a nonthermal method for treating cardiac arrhythmias, and this study aimed to create a functional in vitro model using human-induced pluripotent stem cells (hiPSCs) to explore its underlying mechanisms.
  • Different pulsed-field ablation (PFA) protocols were tested on hiPSC-derived cardiac cells, revealing that PFA can create conduction block areas and demonstrated both reversible and irreversible electroporation effects.
  • Findings indicated that high-frequency PFA was less effective than standard methods and that factors like pulse number and extracellular calcium levels influenced lesion size, with potential applications in controlling arrhythmic activity.
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Background: The ratio between early mitral flow wave to early diastolic mitral annulus velocity (E/e' ratio) varies according to age and sex and is associated with mortality in heart failure. We sought to describe the association between E/e' and mortality in patients with no apparent structural or functional cardiac abnormality and explore possible modifiers of this association.

Methods: A retrospective study of 104,315 patients who underwent echocardiographic evaluation during 2009-2021 in the largest tertiary center in Israel.

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Objectives: Ostial CTOs can be challenging to revascularize. We aim to describe the outcomes of ostial chronic total occlusion (CTO) percutaneous coronary intervention (PCI).

Methods: We examined the clinical and angiographic characteristics and procedural outcomes of 8788 CTO PCIs performed at 35 US and non-US centers between 2012 and 2022.

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Background: New vascular closure devices (VCD) are being introduced for achieving hemostasis after transcatheter aortic valve implantation (TAVI). However, no safety or efficacy data have been published compared to other contemporary VCD.

Aim: To compare the safety and efficacy of suture-based Perclose Prostyle as compared to plug-based MANTA device.

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Background: Levetiracetam is widely used in post-stroke epilepsy. However, it is suspected to possess P-glycoprotein (P-gp) induction properties, and therefore, a potentially significant interaction with direct oral anticoagulants (DOACs). We aimed to search for ischemic stroke signals with levetiracetam and the DOACs.

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Background: Low serum magnesium (sMg) is associated with cardiovascular risk factors and atherosclerotic disease.

Objective: To evaluate the association between sMg levels on admission and clinical outcomes in hospitalized non-ST-elevation myocardial infarction (NSTEMI) patients.

Methods: A retrospective analysis of all patients admitted to a single tertiary center with a primary diagnosis of NSTEMI.

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The advancement of digital biomarkers and the provision of remote health care greatly progressed during the coronavirus disease 2019 global pandemic. Combining voice/speech data with artificial intelligence and machine-based learning offers a novel solution to the growing demand for telemedicine. Voice biomarkers, obtained from the extraction of characteristic acoustic and linguistic features, are associated with a variety of diseases and even coronavirus disease 2019.

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Background: The association between mildly impaired renal function with all-site and site-specific cancer risk is not established. We aim to explore this association among apparently healthy adults.

Methods: We followed 25,073 men and women, aged 40-79 years, free of cancer or cardiovascular disease at baseline who were screened annually in preventive healthcare settings.

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Background: The association between mildly decreased renal function and cardiovascular (CV) outcomes in cancer patients remains unestablished.

Aims: We sought to explore this association in asymptomatic self-referred healthy adults.

Method: We followed 25, 274 adults, aged 40-79 years, who were screened in preventive healthcare settings.

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Objectives: In October 2020 and March 2021, the U.S. Food and Drug Administration (FDA) classified lamotrigine as a class IB antiarrhythmic, announcing an increased risk of heart rhythm problems.

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Background: Transcatheter edge-to-edge mitral valve repair (TEER) has been established as a therapy for severe symptomatic mitral regurgitation (MR) in stable patients, and it has recently emerged as a reasonable option for acutely ill patients. The aim of this study was to evaluate the safety and efficacy of TEER in hospitalized patients with acute decompensated heart failure (ADHF) and severe MR that was deemed to play a major role in their deterioration.

Methods: We included 31 patients who underwent emergent TEER for MR ≥ 3+ from 2012 to 2022 at Sheba Medical Center.

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Article Synopsis
  • * Patients with baseline AF (2% of the total) tended to be older, predominantly male, and had more comorbidities, while male sex, age, obesity, and heart-related issues were identified as strong predictors of AF.
  • * Among those without baseline AF, 85 new cases were identified during follow-up, with age, heart failure, and congenital heart disease being significant risk factors; the CHARGE-AF risk score proved to be a better predictor of AF than the CHADS-VAS
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