Publications by authors named "Ela V Minasyan"
Article Synopsis
- A new method for creating enantiomerically enriched (S)-α-aminopropionic acid derivatives was developed using a reaction called Cu(I) catalyzed [3 + 2] cycloaddition, which combines azides with alkynes.
- The process started with a specific nickel complex and involved several key chemical components, including Schiff bases and phenyl azides.
- The absolute configuration and purity of the resulting amino acids were confirmed through advanced techniques like circular dichroism and chiral HPLC analysis, leading to the successful synthesis of seven new non-proteinogenic (S)-α-amino acids.
A new family of Cu(II) and Ni(II) salen complexes was synthesized and fully characterized through various physicochemical methods. Their catalytic activity was evaluated in the phase transfer C-alkylation reaction of the Schiff bases of D,L-alanine ester and benzaldehyde derivatives. It was found that the introduction of a chlorine atom into the - and -positions of the phenyl ring of the substrate resulted in an increase in both the chemical yield and the asymmetric induction ( 66-98%).
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