Navigating Toxicity: Investigating the Interplay Between Workplace Gaslighting, Workaholism, and Agility Among Nurses.

Toxic workplace environments, especially those involving gaslighting, are known to contribute to stress and excessive work habits, such as workaholism, which may hinder a nurse's agility-an essential skill in adapting to fast-paced healthcare environments. However, the interplay between workplace gaslighting, workaholism, and agility in nursing remains underexplored. This study aims to investigate the relationship between workplace gaslighting, workaholism, and agility among nurses, focusing on how gaslighting moderates this relationship.

Evaluation of the results of reconstruction of large bony defects of humerus using vascularized bone grafts.

Background: Vascularized bone grafts (VBGs) are currently the main surgical option for the restoration of humeral bone defects particularly when defects are larger than 6 cm. Because it offers a strong, rapid blood supply, VBGs easily integrate into the recipient sites and undergo active resorption and remodeling into healthy bone through primary bone healing. Additionally, they support the recipient site's immune system in preventing and reducing infection.

Assessment of a new protocol strategy to control the ectoparasitic infestation in Nile tilapia (Oreochromis niloticus) using efficient natural products.

This study aimed to evaluate alternative in vivo treatment trials using natural products for ectoparasitic infestation on Nile tilapia; these two products were not previously used in the treatment of parasitic fish diseases. So, a total of 400 Oreochromis niloticus (O. niloticus) fish measured 10-15 cm in length; 350 from a fish farm in (Kafr Elsheikh and 50 from Nile River (Al Bahr Al Aazam), Egypt.

S6K2 in Focus: Signaling Pathways, Post-Translational Modifications, and Computational Analysis.

S6 Kinase 2 (S6K2) is a key regulator of cellular signaling and is crucial for cell growth, proliferation, and survival. This review is divided into two parts: the first focuses on the complex network of upstream effectors, downstream modulators, and post-translational modifications (PTMs) that regulate S6K2 activity. We emphasize the dynamic nature of S6K2 regulation, highlighting its critical role in cellular homeostasis and its potential as a therapeutic target in diseases like cancer.

Clinical impact of PTEN rs701848 as a predictive marker for breast cancer.

Background: The incidence of Breast cancer (BC) is currently augmented and it has become the most common malignant cancer in females. Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene as a result of blocking the phosphorylation of PIP3 in PI3K pathway.

Methods: The computational bioinformatics tools were performed to determine the link between PTEN rs701848T/C genetic variants and breast cancer progression.

Pre-stack seismic inversion for reservoir characterization in Pleistocene to Pliocene channels, Baltim gas field, Nile Delta, Egypt.

The Nile Delta, North Africa's leading gas-producing region, was the focus of this study aimed at delineating gas-bearing sandstone reservoirs from the Pleistocene to Pliocene formations using a combination of pre-stack inversion and rock physics analysis. This research employed seismic inversion techniques, including full-angle stack seismic volumes, well logs, and 3-D with rock physics modeling to refine volumes of P-wave velocity (Vp), S-wave velocity (Vs), and density. Traditional seismic attributes, such as far amplitude, proved insufficient for confirming gas presence, highlighting partial angle stacks, integrated the need for advanced methods.

Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature's secrets in forensic science.

The integration of phytochemistry into forensic science has emerged as a groundbreaking frontier, providing unprecedented insights into nature's secrets through the precise application of phytochemical fingerprinting of phytotoxins as a cutting-edge approach. This study explores the dynamic intersection of phytochemistry and forensic science, highlighting how the unique phytochemical profiles of toxic plants and their secondary metabolites, serve as distinctive markers for forensic investigations. By utilizing advanced techniques such as Ultra-High-Performance Liquid Chromatography (UHPLC) and High-Resolution Mass Spectrometry (HRMS), the detection and quantification of plant-derived are made more accurate in forensic contexts.

New thiazolidin-4-ones as anti-cervical cancer agents targeting EGFR: design, synthesis, and computational studies.

Aim: A new series of 3,4-dihydronaphthalen-1(2 h)-ylidene)hydrazineylidene)-5-substituted thiazolidin-4-one derivatives were designed and synthesized.

Results & Methodology: The new compounds were screened for in vitro antitumor activity against Hela cancer cell line. The compounds 7b, 7 h, and 7i produced more potent cytotoxicity than doxorubicin with IC values of 1.

Risk assessment and natural radionuclide content in black-sand deposits of North Sinai coast, Egypt.

The radioactivity levels and risk factors have been assessed for twenty-eight positions of Black-Sand (BS) surface deposits along the Mediterranean Sea coast of north Sinai, Egypt. Twenty-eight surface samples were collected from six local cities: El Ressa, Abo Sakl, Ghornata, El Arish, El Masaed, and El Rommana. The activity concentration values of the nuclides of the Ra, Th, and K of the collected samples were measured using a P-type HPGe detector with a relative efficiency of ∼100% where it is defined at 1.

The role of artificial intelligence literacy and innovation mindset in shaping nursing students' career and talent self-efficacy.

Background: As artificial intelligence (AI) transforms nursing education, AI literacy is becoming a critical necessity for increasing the career potential and talent of nursing students. Additionally, fostering an innovation mindset promotes adaptability, creativity and openness to new approaches, further boosting students' confidence in their careers. However, few studies have examined the impact of these competencies on nursing students' career and talent self-efficacy, underscoring the need for further investigation.

Utilizing post-stack seismic inversion for delineation of gas-bearing sand in a pleistocene reservoir, baltim gas field, nile delta, Egypt.

Given useful rock properties, gas sands generally appear as bright events on seismic data. Unfortunately, partially saturated gas sands tend to be of similar brightness to fully saturated gas sands so cannot be distinguished easily. Seismic inversion can sometimes help, given adequate seismic data and a robust understanding of rock physics.

International nursing students' culture shock and academic engagement: The moderating role of resilience.

Background: The nursing profession has experienced a growing influx of international nursing students pursuing nursing degrees in the current era. Predicting and controlling culture shock among this special group is a critical issue as it shapes their academic engagement. Building resilience capabilities among this set of students is a pivotal necessity to buffer the effect of culture shock on their academic engagement.

Navigating transition shock: The role of system thinking in enhancing nursing process competency among early career nurses.

Background: Building nursing process competency among beginner nurses is a pivotal need in contemporary, complex, fast-paced nursing practice. However, transitioning from the educational phase to practicing as a nurse can be a significant adjustment. New practitioners often experience a period of shock, which may present challenges in developing nurse competency.

Lower trapezius transfer to infraspinatus in cases of sequelae of obstetric brachial plexus injury.

Background: Deficient shoulder function is a common and exhausting issue in children with obstetric brachial plexus injuries. Even with functioning elbow, wrist, and fingers, upper limb function is markedly disabled by limited shoulder abduction external rotation. Lower trapezius transfer carries many advantages; simple and safe technique, same line of pull as donor; reliable nerve supply (extraplexal from spinal accessory nerve), and not acting on rotation of the shoulder, mostly it will not adversely affect internal rotation range after the transfer.

Biological control of nosemosis in Apis mellifera L. with Acacia nilotica extract.

Nosemosis is one of the most devastating diseases of Apis mellifera (Honey bees) caused by the single-celled spore-forming fungi Nosema apis, N. ceranae and N. neumanii, causing a severe loss on the colony vitality and productivity.

Economic Burden of Haemophilia from a Societal Perspective: A Scoping Review.

Introduction: Haemophilia is a rare genetic bleeding disorder that leads to musculoskeletal complications. The high cost of haemophilia treatment necessitates a thorough evaluation of its economic burden. However, due to the difficulty of estimating direct non-medical, indirect, and intangible costs, studies often underestimate the actual economic burden of haemophilia.

DNA barcoding, micromorphology and metabolic traits of selected Ficus L. (Moraceae) species from Egypt.

The genus Ficus of the family Moraceae, is one of the largest genera of angiosperms, with diverse pharmaceutical applications and biological activities. The traditional approaches based on the morphological traits have been frequently implemented for taxonomical identification of the different taxa of Ficus, however, encompassing these features are quite laborious, due to the dependence of these phenotypic traits on the environmental conditions. So, authenticating the taxonomical identity of the Ficus taxa with molecular barcoding and metabolic profiling, as relatively stable traits, could be a relevant approach for confirming the traditional phenotypic traits of this genus.

Aspergillus flavipes L-methionine γ-lyase-β-cyclodextrin conjugates with improved stability, catalytic efficiency and anticancer activity.

Aspergillus flavipes L-methionine γ-lyase (MGL) has been authenticated as a powerful anticancer agent towards various solid tumors, however, the catalytic efficiency and stability of this enzyme remains the main challenge for its further in vivo applications. Thus, the objective of this study was to enhance the catalytic efficiency, structural stability of A. flavipes MGL, in addition to boost their anticancer activity, via conjugation with β-cyclodextrin.

Novel 5-Fluorouracil analogues versus perfluorophenyl ureas as potent anti-breast cancer agents: Design, robust synthesis, in vitro, molecular docking, pharmacokinetics ADMET analysis and dynamic simulations.

To investigate the therapeutic potential of 5-Fluorouracil-based analogues, a straightforward synthetic technique was employed to synthesize a novel series of 5-arylurea uracil derivatives (AUFU01-03) and aryl-urea derivatives bearing perfluorophenyl (AUPF01-03). Reliable tools such as infrared (IR), Nuclear Magnetic Resonance (NMR) spectra, and elemental analyses were utilized to confirm the chemical structures and purity of these compounds. In comparison to healthy noncancerous control skin fibroblast cells (BJ-1), we examined the antiproliferative efficacy of compounds (AUFU01-03) and (AUPF01-03) against specific human malignant cell lines of the breast (MCF-7), and colon (HCT-116).

The Climate-Asthma Connection: Examining the Influence of Climate Change Anxiety on Asthma Control and Quality of Life: A Multi-National Study.

Aims: This study aims to identify the impact of climate change anxiety and asthma control on asthmatics' quality of life and examine the moderating role of climate change anxiety in this linkage.

Method: A multi-national cross-sectional study was conducted in four Arabian countries on 1266 asthmatics selected by convenience sampling. Data were collected from November 2023 to February 2024 using a climate anxiety scale, mini-asthma quality of life questionnaire, and an asthma control questionnaire.

Outcomes of Surgical Revascularization for Acute Upper Limb Ischemia- A Single-Center Retrospective Analysis.

Background: Acute upper limb ischemia (AULI) is a medical emergency with high perioperative complication rates; however, these are poorly reported. The aim of this study is to report the complication rates following surgical revascularization in AULI.

Methods: Retrospective analysis of all patients undergoing brachial embolectomy for AULI from January 2010 to October 2021 was included.