Effect of urea on the activity of certain ophthalmic drugs in man.

The role displayed by urea (2-10%) solutions, on the miotic and mydriatic activities of pilocarpine hydrochloride and homatropine hydrobromide respectively, was investigated on the human eye. At different concentrations, urea exerts no effect on the miotic activity of pilocarpine, whereas in the case of homatropine a negative effect is experienced. For the parameters, area under pupil diameter--time curve (AUC) and maximum pupillary response (MPR), a linear relationship exists between response to homatropine and urea concentration.

Quantitative Changes in Carbohydrates and Acidity during Manufacture of Low-Lactose Zabadi.

B-galactosidase from Saccharomyces lactis was used to hydrolyze lactose in buffalo milk from which Zabadi was made. The lactose content of Zabadi samples decreased with increasing the amount of β-galactosidase used for hydrolysis of the buffalo milk from which Zabadi was made. Also, higher product scores were given to Zabadi samples made from treated milk that contained 28.

Interaction between phenylephrine hydrochloride and polyethylene glycol 400.

Evidence of complexing tendency of the water-soluble polymer polyethylene glycol 400 (PEG 400) and phenylephrine hydrochloride was supported by the equilibrium dialysis method. The influence of polymer concentration, ionic concentration, and hydrogen ion concentration of the systems on the interaction was investigated. Attempts to separate the complex by using paper chromatographic techniques have also been made.

A paper chromatographic method for separation and determination of synephrine in injectable solutions.

A new analytical method using ascending paper chromatographic technique was developed for identification and quantitative determination of residual synephrine in fresh and deteriorated samples. This method was found to be stability indicating; one to five degradation products have been successfully separated from drug samples subjected to accelerated stability testing at 60 degrees C for 3 months.

Influence of diet on breeding and infectivity in mass cultivation of Bulinus truncatus.

Under well defined laboratory conditions as troughs, room temperature, humidity, water, and air supply Bulinus truncatus was bred and kept. In a feeding trial high protein diet consisting of powdered mice pellets, commercial tropical fish food and lettuce was compared to poor protein diet of lettuce alone. Higher yield of clutches, eggs and cercariae were observed in the rich protein diet group, Bulinus and Biomphalaria Snail seem to be influenced by diet in the same way.

Studies on the stability of injectable solutions of some phenothiazines. Part 2: Effect of chelating agents and antioxidants.

Chelating agents (disodium EDTA, DTPA, HEDTA and NTA) exhibit a stabilizing action towards phenothiazines to different extents. This could be correlated to the stability constants of their metal chelates as well as to the dependency of these constants on the pH-value of the solution. Antioxidants (sodium bisulphite, sodium dithionite, and sodium metabisulphite) also exert a stabilizing effect which could be correlated--in the first place--to the pH-value of the solution.

[Studies on the stability of injectable solutions of some phenothiazines. Part 1: Effects of pH and buffer systems].

The stability of phenothiazines is affected by the pH-value of the solution. At the pH-values of maximum stability, triflupromazine hydrochloride and chlorpromazine hydrochloride are more stable than promazine hydrochloride. The stability of chlorpromazine hydrochloride in the Sörensen's phosphate buffer is slightly higher than that in the McIlvaine's citric acid-phosphate buffer system.

On the racemization of L-noradrenaline bitartrate.

The hydronium ion catalyzed racemization of L-noradrenaline bitartrate solutions was studied as a function of ionic strength and polarity of the medium. On the grounds of the findings obtained, it was assumed that the racemization of the drug involves an ionic reaction between ions of like charge. The water/propylene glycol system dielektric constant 60 was found to furnish optimal stability conditions for the drug.