Background And Objectives: Pediatric patients with acute disseminated encephalomyelitis (ADEM) are at risk of impaired brain growth, with long-term neuropsychiatric consequences. We previously reported transient expansions of cerebral ventricle volume (VV) in experimental autoimmune encephalomyelitis, which subsequently normalized. In this study, we investigated changes in VV in ADEM in relation to other brain structures and clinical outcomes.
View Article and Find Full Text PDFMult Scler Relat Disord
December 2024
Eur J Paediatr Neurol
November 2024
Background: Narcolepsy is a rare neurological disease caused by dysfunction of hypocretin-producing neurons. Hypocretin concentrations in the cerebrospinal fluid (CSF) of less than 110 pg/ml are considered pathological in adults.
Objectives: To compare hypocretin levels of children with narcolepsy type 1, type 2 and disease control groups, in addition to a detailed CSF analysis, clinical and polysomnographic parameters.
Introduction: Neuroimmunological diseases such as autoimmune encephalitis (AE) or acquired demyelinating syndromes (ADS), can present with neurological symptoms and imaging features that are indistinguishable from mitochondrial diseases (MD) in particular at initial presentation.
Methods: Retrospective analysis of the clinical, laboratory and neuroimaging features of five patients who presented with signs of a neuroimmunological disease but all had pathological pathogenic variants in genes related to mitochondrial energy metabolism.
Results: Four patients presented with an acute neurological episode reminiscent of a possible AE and one patient with a suspected ADS at initial presentation.
Mult Scler Relat Disord
November 2022
Polyaniline titanotungstate (PATiW) was synthesized by the sol-gel method. Adsorption isotherm studies of Cs(+) from aqueous solution are described. Elemental Composition, chemical solubility, ion-exchange capacity (IEC) and pH-titration curve are studied.
View Article and Find Full Text PDFSynthetic magneso-silicate and magnesium alumino-silicate as inorganic ion exchange materials with the formula MgSi5.59O(12.18).
View Article and Find Full Text PDFTwo novel inorganic ion exchange materials magneso-silicate and magnesium alumino-silicate have been synthesized under identical conditions. The structure of these materials was established by chemical analysis, X-ray diffraction, thermogravemetric and differential thermal analyses, Fourier transform infrared spectroscopy and X-ray fluorescence analysis. Magneso-silicate and magnesium alumino-silicate were found to have the formulas MgSi(5.
View Article and Find Full Text PDFIt has become apparent that hepatitis C virus (HCV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC) worldwide. The precise mechanism by which HCV causes HCC is not known. Unlike the hepatitis B virus (HBV), HCV is not a DNA virus and does not become integrated within the genome of hepatocytes.
View Article and Find Full Text PDFBackground: Neopterin is derived from guanosine triphosphate and is produced by stimulated macrophages under the influence of gamma-interferon of lymphocyte origin. It has been suggested that it is an excellent marker for the activation of the monocyte/macrophage axis in some clinical situations. However, to our knowledge, the relationship of BAL neopterin levels to disease states has not been studied.
View Article and Find Full Text PDFThe kinetic behaviour of Cl(-), Br(-) and SCN(-) exchanges on hydrous tin oxide have been investigated under conditions of particle diffusion and the limited bath technique. Values for the diffusion coefficients, energy of activation and entropy of activation have been calculated. The data obtained have been compared with those reported for other organic and inorganic exchangers.
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