Publications by authors named "El-Meliegy A"

Article Synopsis
  • Non-obstructive azoospermia (NOA) is a prevalent and complex issue with varied treatment options and no definitive guidelines, leading to differing management practices internationally.
  • A comprehensive survey with 336 responses from specialists in 49 countries explored current medical and surgical strategies for NOA, analyzing results against existing guidelines and offering expert recommendations.
  • Key findings included diverse approaches to hormonal therapy, significant variation in sperm retrieval success rates, and differing protocols around varicocele repair and follicle-stimulating hormone cutoff levels for sperm retrieval.
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Article Synopsis
  • * Conducted from July to September 2022, a questionnaire gathered responses from 367 doctors in 49 countries, focusing on how they diagnose NOA through methods like hormone tests and genetic analyses.
  • * The survey identified that while many practices align with guidelines, significant differences in approaches were found, underscoring the need for standardized, evidence-based international guidelines for NOA evaluation.
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Purpose: Varicocele is a common problem among infertile men. Varicocele repair (VR) is frequently performed to improve semen parameters and the chances of pregnancy. However, there is a lack of consensus about the diagnosis, indications for VR and its outcomes.

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Objectives: To highlight alternative treatment options other than exogenous testosterone administration for hypogonadal men with concomitant infertility or who wish to preserve their fertility potential, as testosterone replacement therapy (TRT) inhibits spermatogenesis, representing a problem for hypogonadal men of reproductive age.

Materials And Methods: We performed a comprehensive literature review for the years 1978-2017 via PubMed. Also abstracts from major urological/surgical conferences were reviewed.

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Introduction: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer.

Aim: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning management strategies for post-RP erectile function impairment and to analyze post-RP sexual dysfunction other than erectile dysfunction.

Methods: A literature search was performed using Google and PubMed database for English-language original and review articles published up to August 2016.

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Introduction: Sexual dysfunction is common in patients after radical prostatectomy (RP) for prostate cancer.

Aim: To provide the International Consultation for Sexual Medicine (ICSM) 2015 recommendations concerning prevention and management strategies for post-RP erectile function impairment in terms of preoperative patient characteristics and intraoperative factors that could influence erectile function recovery.

Methods: A literature search was performed using Google and PubMed databases for English-language original and review articles published up to August 2016.

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Introduction: Testosterone deficiency (TD), also known as hypogonadism, is a condition affecting a substantial proportion of men as they age. The diagnosis and management of TD can be challenging and clinicians should be aware of the current literature on this condition.

Aim: To review the available literature concerning the diagnosis and management of TD and to provide clinically relevant recommendations from the Fourth International Consultation for Sexual Medicine (ICSM) meeting.

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Introduction: Treatment of erectile dysfunction is based on pharmacotherapy for most patients.

Aim: To review the current data on pharmacotherapy for erectile dysfunction based on efficacy, psychosocial outcomes, and safety outcomes.

Methods: A review of the literature was undertaken by the committee members.

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Article Synopsis
  • In 2014, the International Society for Sexual Medicine (ISSM) formed a panel to create evidence-based guidelines for diagnosing and managing testosterone deficiency (TD) in adult men, covering aspects such as definition, causes, and treatment options.
  • The aim was to produce practical recommendations for non-endocrinology clinicians, like those in family medicine and general urology, to effectively diagnose and treat TD.
  • The panel's findings provide a clear definition of TD, suggestions for assessment and treatment across various populations, and emphasize the need for ongoing research and future updates to the guidelines.
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Introduction: Chronic prostatitis is a common urological problem in men <50-year-old. Untypical uropathogens and an intact blood prostate barrier cause difficulty in using antibiotics to treat the infection.

Patients And Methods: In this open-label, observational study, levofloxacin 500 mg was given once daily for 28 days for treatment of chronic prostatitis.

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Background: Phosphodiesterase type 5 (PDE5) inhibitors have discontinuation rates as high as 60% in men with erectile dysfunction. Treatment satisfaction has been significantly associated with treatment continuation. Understanding key characteristics in terms of treatment preference, relationship, and lifestyle issues could provide direction on how to improve compliance with PDE5 inhibitor treatment globally.

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Background: Erectile dysfunction (ED) negatively impacts quality of life. Phosphodiesterase type 5 inhibitors (PDE5Is) are effective in treating ED; however, rates of discontinuation remain high.

Objectives: To assess on-demand PDE5I treatment persistence and adherence through 6 months in Middle Eastern and North African (MENA) men with ED in a prospective, non-interventional, observational trial.

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Introduction: Over the past 20 years our knowledge of premature ejaculation (PE) has significantly advanced. Specifically, we have witnessed substantial progress in understanding the physiology of ejaculation, clarifying the real prevalence of PE in population-based studies, reconceptualizing the definition and diagnostic criterion of the disorder, assessing the psychosocial impact on patients and partners, designing validated diagnostic and outcome measures, proposing new pharmacologic strategies and examining the efficacy, safety and satisfaction of these new and established therapies. Given the abundance of high level research it seemed like an opportune time for the International Society for Sexual Medicine (ISSM) to promulgate an evidenced-based, comprehensive and practical set of clinical guidelines for the diagnosis and treatment of PE.

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Introduction: Pharmacotherapy is the usual initial therapy for most men with erectile dysfunction.

Aim: To review the current data relating to the efficacy, tolerability and safety of drugs used in the treatment of men with erectile dysfunction.

Methods: A critical review of the literature relating to the use of pharmacotherapeutic agents was undertaken by a committee of eight experts from five countries, building on prior reviews.

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The objective of this retrospective study is to evaluate the surgical outcome of correction of congenital penile curvature, via multiple vertical incisions in the tunica albuginea that are sutured horizontally using simple inverted 2-0 PDS sutures. The study included 22 men with congenital penile curvature. The surgeries were performed in three general hospitals.

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Objective: To evaluate the effectiveness of the technique of corporeal counter incisions for penile prosthesis implantation in cases with marked corporeal fibrosis.

Methods: Creating subtunical tunnels that are stretched transversely by the dilamezinsert instrument & Heggars dilators with its tip entering from one side and protruding from the counter incision to avoid urethral or corporeal perforation.

Patients: Seventeen patients underwent this technique, mean age 56 y (range 42-71 y); 12 post removal of an infected prosthesis and five post priapism.

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The objective of this retrospective study is to evaluate the surgical outcome with malleable penile implants without plaque surgery in the treatment of impotence associated with Peyronie's disease. This study included 20 men with Peyronie's disease who underwent placement of a malleable penile prosthesis. The surgeries were performed in three day surgery units in Cairo and Jeddah.

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