In silico research on new sulfonamide derivatives as BRD4 inhibitors targeting acute myeloid leukemia using various computational techniques including 3D-QSAR, HQSAR, molecular docking, ADME/Tox, and molecular dynamics.

Acute myeloid leukemia, a serious condition affecting stem cells, drives uncontrollable myeloblast proliferation, leading to accumulation. Extensive research seeks rapid, effective chemotherapeutics. A potential option is a BRD4 inhibitor, known for suppressing cell proliferation.

Radiological impact of natural radioactivity in Egyptian phosphate rocks, phosphogypsum and phosphate fertilizers.

In this study, the activity concentrations of the natural radionuclides in phosphate rocks and its products were measured using a high- purity germanium detector (HPGe). The obtained activity results show remarkable wide variation in the radioactive contents for the different phosphate samples. The average activity concentration of U, U, Ra, Th and K was found as (45, 1031, 786, 85 and 765Bq/kg) for phosphate rocks, (28, 1234, 457, 123 and 819Bq/kg) for phosphate fertilizers, (47, 663, 550, 79 and 870Bq/kg) for phosphogypsum and (25, 543, 409, 54 and 897Bq/kg) for single super phosphate respectively.

Natural radioactivity levels for selected kinds of Egyptian sand.

The monitoring and evaluation of natural radioactivity content of sixty-five different samples of sand used in building materials, black sand and its components, and therapy sand collected from different locations in Egypt have been investigated. The specific radioactivity concentration of 238U, 232Th series, and 40K were measured by gamma-ray spectrometer using a shielded HPGe. The obtained results of 238U and 232Th series as well as 40K are discussed.

Standardization of cytokine flow cytometry assays.

Background: Cytokine flow cytometry (CFC) or intracellular cytokine staining (ICS) can quantitate antigen-specific T cell responses in settings such as experimental vaccination. Standardization of ICS among laboratories performing vaccine studies would provide a common platform by which to compare the immunogenicity of different vaccine candidates across multiple international organizations conducting clinical trials. As such, a study was carried out among several laboratories involved in HIV clinical trials, to define the inter-lab precision of ICS using various sample types, and using a common protocol for each experiment (see additional files online).

Assessment of radioactivity and radon exhalation rate in Egyptian cement.

The cement industry is considered as one of the basic industries that plays an important role in the national economy of developing countries. Activity concentration of 238U, 232Th, and 40K in local cement types from different Egyptian factories has been measured using a shielded HPGe detector. The average values obtained for 238U, 232Th, and 40K activity concentrations in different types of cement are lower than the corresponding global values reported in UNSCEAR publications.

Elemental analysis of Egyptian phosphate fertilizer components.

The accumulation of certain elements in vitally important media such as water, soil, and food is undesirable from the medical point of view. It is clear that the fertilizers vary widely in their heavy metals and uranium content. A shielded high purity germanium HPGe detector has been used to measure the natural concentration of 238U, 232Th, and 40K activities in the phosphate fertilizer and its components collected from Abu-Zaabal fertilizers and chemical industries in Egypt.

Radioactivity in local and imported kaolin types used in Egypt.

Natural radioactive materials are present in all geological rocks in varying amounts, they are easily mobilized in the environment, and can reach hazardous radiological levels under certain conditions, requiring precautions to be taken. The present study deals with 50 geological samples of local (Tushki and Kalabsha in upper Egypt) and imported (southeast Asia and Turkey) kaolin types. The samples were analyzed by gamma-ray spectroscopy using a HPGe detector.

Radioactivity levels of salt for natural sediments in the northwestern desert and local markets in Egypt.

Thirteen samples of salt collected from different locations of old sediments in the western desert at El-Harra and Ain Giffara, Sitra lake and local markets in Egypt have been investigated. Natural radionuclide contents have been measured by gamma-ray spectrometry employing a shielded HPGe detector. The activities of 238U, 232Th and 40K have been determined in Bq/kg dry weight.

Lymphoepithelial interactions trigger specific regulation of gene expression in the M cell-containing follicle-associated epithelium of Peyer's patches.

In the intestine, the follicle-associated epithelium (FAE) of Peyer's patches (PP) performs Ag sampling as the first step in developing immune responses. Depending on the species, this epithelium contains 10-50% of M cells, which act as regulated gates in epithelial barriers that can be used opportunistically by pathogens to invade their host. However, the mechanisms involved in the differentiation and uptake processes of M cells are not known, in part because their limited number in the intestinal mucosa has hampered molecular and biochemical studies.

Natural radioactivity and radon exhalation rate of soil in southern Egypt.

The level of natural radioactivity in soil of 30 mining samples collected from six locations in southern Egypt was measured. Concentrations of radionuclides in samples were determined by gamma-ray spectrometer using HPGe detector with a specially designed shield. The obtained results of uranium and thorium series as well as potassium (K-40) are discussed.

Elemental investigation of some Egyptian vehicle motor alloys using neutron activation analysis.

Six samples of different Egyptian motor vehicle alloys have been investigated by neutron activation analysis to estimate the concentrations of their elemental constituents, which affect their quality. A single high resolution hyper-pure germanium HPGe gamma-ray detector and a multichannel analyzer are used to collect the gamma-ray spectra. A HPGe-HPGe coincidence spectrometer was also used to confirm the identity of certain peaks.

Heavy metals and rare earth elements in phosphate fertilizer components using instrumental neutron activation analysis.

The technique of instrumental neutron activation analysis was applied as a sensitive nondestructive analytical tool for the determination of heavy metals and rare earth elements in phosphate fertilizer ingredients. The contents of heavy metals Fe, Zn, Co, Cr and Sc as well as rare earth elements La, Ce, Hf, Eu, Yb and Sm were determined in four samples representing the phosphate fertilizer components (e.g.

Mouse Alx3: an aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm.

Mouse Alx3 is a homeobox gene that is related to the Drosophila aristaless gene and to a group of vertebrate genes including Prx1, Prx2, Cart1, and Alx4. The protein encoded contains a diverged variant of a conserved peptide sequence present near the carboxyl terminus of at least 15 different paired-class-homeodomain proteins. Alx3 is expressed in mouse embryos from 8 days of gestation onward in a characteristic pattern, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm.