Isolation of holostane-type saponins from the black sea cucumber and evaluating their anti-allergic activity: in vitro and in silico study.

Unlabelled: Sea cucumbers are both versatile marine organisms and an Asian marine food known to have several medicinal effects. We evaluated the anti-allergic potential of some major purified holostane-type saponins from the body wall of the black sea cucumber, . Six saponin compounds were isolated, holothurin B (), holothurin A (), 24-dehydro echinoside A (), desholothurin A1 (), desholothurin A (), and des 24-dehydro echinoside A ().

Microplastics in marine invertebrates from the Red Sea Coast of Egypt: Abundance, composition, and risks.

This study marked the first exploration of microplastics in marine invertebrates in the Red Sea Coast of Egypt. 110 individuals from 11 different species, including Bivalvia, Gastropoda, Echinoidea, and Holothuroidrea, were collected near a popular tourist destination. The average concentrations of microplastics varied among species, ranging from 8.

Cytotoxic evaluation of new polyhydroxylated steroids from the Red Sea soft coral (Macfadyen, 1936).

An efficient column chromatography of the CHCl/MeOH crude extract from the soft coral (Macfadyen, 1936) yielded seven steroids, including five 4α-methylated steroids () and two 19-oxygenated steroids (). Notably, both compounds and are new, identified as (22)-4α,24-dimethyl-5α-cholesta-22,24(28)-dien-3β,8β-diol () and (22,24)-7β-acetoxy-24-methyl-cholesta-5,22-dien-3β,19-diol (). The chemical structures and relative configurations were elucidated through comprehensive spectroscopic analyses, including 1D and 2D NMR, as well as HRESIMS analysis.

New Cytotoxic Monoalkyl Glycerol Ether from the Red Sea Soft Coral Nephthea mollis.

A new monoalkyl glycerol ether, 3-(n-henicosyloxy)propane-1,2-diol (1), was isolated from the CH Cl /MeOH crude extract of the Red Sea soft coral Nephthea mollis. Additionally, three known related analogs were identified: chimyl alcohol (2), batyl alcohol (3), and 3-(icosyloxy)propane-1,2-diol (4). The chemical structure of 3-(n-henicosyloxy)propane-1,2-diol was determined using advanced spectroscopic analyses, including 1D, 2D Nuclear Magnetic Resonance (NMR), Electron Ionization mass spectra (EI-MS), and High-Resolution Electron Spray Ionization mass spectra (HR-ESI-MS) analyses.

Comparing genetic markers efficiencies for discrimination between two commercially important holothuroids in the Mediterranean Sea, Holothuria polii and Holothuria sanctori.

Sea cucumber (bche-de-mer, Echinodermata: Holothuroidea) is one of the top internationally traded seafood varieties. Besides its direct nutritional benefits, it is continuously used in the traditional medicine in different areas and cultures in the world. This world-wide interest triggered various issues related to stocks declining and risks of species extinction.