[Effects of non-clostridial anaerobic infection on the course of chronic pulmonary tuberculosis in experimental animals].

Influence of non-clostridial anaerobic infection on the course of chronic pulmonary tuberculosis caused by intrapleural administration of BCG used in a vaseline-lanolin mixture was studied experimentally on guinea pigs. Administration of Bacteroides fragilis in the presence of a mild tuberculous inflammation aggravates the course of a specific process promoting pleural empyema development, increase in the size of pulmonary granuloma, extension of pathologic changes into the parenchymatous organs and aggravation of a nonspecific inflammatory reaction. Animals with mixed infection exhibited a longer duration and higher level of M.

[The etiologic significance of ultrafine forms of the causative agent of tuberculosis in the development of sarcoidosis of the respiratory organs].

Pathological material, i. e. bronchoalveolar lavage fluid (BALF) and blood plasma from patients with various pathological processes in the lungs was studied.

[Dynamics of the shedding of bacterial and ultrafine forms of mycobacteria during the chemotherapy of patients with pulmonary tuberculosis].

The specific features of bacterial excretion by patients with pulmonary tuberculosis in the process of chemotherapy, depending on the duration of treatment, have been studied, and the time-course of the excretion of ultramicro forms of mycobacteria by patients with and without caverns in the lungs in the process of chemotherapy has been followed. The results of the detection of M. tuberculosis ultramicro forms with the use of the biological and bacteriological methods indicate that both these methods are highly effective and informative.

[Structural changes in the thymus in experimental tuberculosis].

Structural and functional alterations in the thymus in experimental tuberculosis are phasic in nature and involve 2 stages. In the early stage of tuberculous process, the morphofunctional status of cell elements of the blood-thymic barrier increases as vascular permeability and lymphocyte migration rise and the synthesis of epithelial cells of the medulla gets activated. During disseminated tuberculosis cell elements of the thymic parenchyma undergo destructive changes as a result of histohematic barrier impairment leading to disturbed homeostasis and organ alterations.

[Lymphoid cell ultrastructure in experimental tuberculous granuloma].

There are two groups of activated cells differing both in ultrastructure and manifestations of functional activity in lymphoid populations participating in the formation of tuberculous granuloma. In group 1 lymphoid cells, the development of intracellular structure is associated with an intense synthetic and secretory activity. Group 2 cells are mainly characterized by absorption function realized by means of active pinocytosis.

[Ultrastructure and function of cellular elements of the thymus during formation of antitubercular immunity].

Electron microscope and histochemical study of the thymus was carried out on growing guinea pigs under normal conditions and during the immune responses in BCG vaccination. During the postvaccinal period, particularly at periods of from 3 to 7 days, there was a change in the cell elements ultrastructure of the hemato-encephalic barrier. The greatest shifts were noted in the reticular and endothelial cells.

[Experimental study of 2d order tuberculostatic preparations in Mycobacterium bovis resistance to isoniazid or streptomycin (based on the data from a morphological study)].

A comparative study on the therapeutic value of the II line drugs (ethoxide, prothionamide, cycloserin) and bacteriostatics (ethambutol anf rifampicin), with their action upon experimental tuberculosis produced by streptomycin- or isoniazid-resistant mycobacteria of the bovine type, was carried out. This showed rifampicin and ethambutol to be mose effective. Ethoxide and prothionamide proved more efficient when acting upon isoniazid-resistant strains.