Preliminary insights on the metabolomics of infection in Sprague Dawley rats using GCxGC-TOF-MS (untargeted approach).

infections have been documented globally and have been detected in wild and/or domestic animals except Antarctica. There is paucity of information in the metabolic responses of hosts during infections and biomarkers for infection that can be used in the diagnosis of the disease. The current study aimed to apply a non-targeted metabolomic approach to identify biomarkers including metabolic response from sera of infected Sprague-Dawley rats.

Chemokine, cytokine and haematological profiles in Sprague-Dawley rats co-infected with ANKA and -A laboratory animal model for malaria and tissue-dwelling nematodes co-infection.

Malaria remains a major cause of mortality and morbidity in sub-Saharan Africa (SSA) and tissue-dwelling helminth parasites (TDHPs) are also prevalent in this region presenting a geographical overlap in endemicity. There is paucity of information on the specific host immune responses elicited at different phases of the life cycle by the co-infecting helminth parasites. This study aimed at using a laboratory animal model to determine selected chemokine, cytokine and hematological profiles in Sprague-Dawley rats co-infected with ANKA (Pb) and a tissue-dwelling nematode, (Tz).