Publications by authors named "Ekta Singh"

The study explores the synthesis and utilization of biochar (BC) and multi-layer MXene to MXene/biochar (MB) composites for wastewater treatment. Simultaneously, it also investigates their energy generation potential through biomass and soil property assessments. The integrated column and batch treatments have shown significant results, elevating total dissolved solids from 63.

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Gaseous nanobubbles (NBs) with dimensions ranging from 1 to 1000 nm in the liquid phase have garnered significant interest due to their unique physicochemical characteristics, including specific surface area, low internal gas pressure, long-term stability, efficient mass transfer, interface potential, and free radical production. These remarkable properties have sparked considerable attention in the scientific community and industries alike. These hold immense promise for environmental applications, especially for carbon-neutral water remediation.

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Liposomes, as a colloidal drug delivery system dating back to the 1960s, remain a focal point of extensive research and stand as a highly efficient drug delivery method. The amalgamation of technological and biological advancements has propelled their evolution, elevating them to their current status. The key attributes of biodegradability and biocompatibility have been instrumental in driving substantial progress in liposome development.

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Recently, the rampant administration of antibiotics and their synthetic organic constitutes have exacerbated adverse effects on ecosystems, affecting the health of animals, plants, and humans by promoting the emergence of extreme multidrug-resistant bacteria (XDR), antibiotic resistance bacterial variants (ARB), and genes (ARGs). The constraints, such as high costs, by-product formation, etc., associated with the physico-chemical treatment process limit their efficacy in achieving efficient wastewater remediation.

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The persistence and transmission of emerging pollutants such as antibiotic resistance genes (ARGs) via mobile genetic elements (MGEs) have caused concern to scientific community. Composting practises are often adapted for the reduction of organic waste or to enhance fertility in agriculture soil but its continuous usage has posed a potential risk of increased abundance of ARGs in soil. Thus, the present study scrutinises the emerging risk of ARGs and MGEs in agriculture soil and its potential mitigation using biochar owing to its proven environmental sustainability and performance.

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The role of arthropods as livestock pests has been well established. Besides their biting habits causing nuisance in animals; they are important vectors for transmission of economically important livestock diseases worldwide. Various pests and vector control managemental programs that also make use of chemicals have variable success rates.

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Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy affecting millions of individuals worldwide. It is believed that the prevalence of G6PD deficiency in different ethnic populations increases its association with other pathological conditions especially sickle cell anemia (SCA), as they both are well-known adaptations against malaria. Thus, the present study aims to determine the frequency of G6PD deficiency among SCA patients and the association between them in the tribal community (Gond) of Chhattisgarh, India.

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This study investigates the synergistic role of carbon dioxide nanobubbles (CNBs) and biochar (BC) on seed germination, plant growth, and soil quality, employing Solanum lycopersicum (tomato) and Phaseolus vulgaris (beans) as test plant species. CNBs, generated and dispersed in both distilled water (DW) and tap water (TW), exhibited distinct characteristics, with TW-CNBs being larger and more stable (peak values of around 18.17 nm and 299.

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Article Synopsis
  • EGFR and HER2 are proteins linked to breast cancer, promoting cell growth and reducing cell death when overexpressed by binding to their ligands.
  • Pyrimidine derivatives have shown potential in inhibiting EGFR and HER2 in various cancer cell lines and animal studies, indicating their effectiveness as cancer treatments.
  • The study emphasizes the importance of structure-activity relationships (SAR) in understanding how different chemical structures affect the activity and toxicity of pyrimidine compounds in targeting these receptors.
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The prevalence of antibiotic traces in the aquatic matrices is a concern due to the emanation of antibiotic resistance which requires a multifaceted approach. One of the potential sources is the wastewater treatment plants with a lack of advance infrastructure leading to the dissemination of contaminants. Continuous advancements in economic globalization have facilitated the application of several conventional, advanced, and hybrid techniques for the mitigation of rising antibiotic traces in the aquatic matrices that have been thoroughly scrutinized in the current paper.

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Alzheimer's disease (AD) is the leading cause of dementia, affecting millions of people worldwide. Oxidative stress contributes towards induction of neurodegeneration. It is one of the reasons behind initiation and progression of Alzheimer's disease.

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Environmental contamination is considered a major issue with the growing urbanization and industrialization. In this context, the scientific society is engaged in searching for a sustainable, safe, and eco-friendly solution. Sustainable materials such as biochar play an important role in environmental contamination.

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Article Synopsis
  • Novel drug delivery systems (DDS) are focusing on smart biomaterials that enable localized and on-demand drug release in response to various stimuli, enhancing treatment effectiveness.
  • Biodegradable polymers are commonly used for long-term drug release but can face issues like dose dumping; smart biomaterials aim to address these challenges by releasing drugs only when needed.
  • The review highlights advancements in electrically conductive polymers, their diverse applications in drug delivery, biosensing, and tissue engineering, and discusses their structural and functional properties along with future research directions.
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Ferroelectric domain boundaries are quasi-two-dimensional functional interfaces with high prospects for nanoelectronic applications. Despite their reduced dimensionality, they can exhibit complex non-Ising polarization configurations and unexpected physical properties. Here, the impact of the three-dimensional (3D) curvature on the polarization profile of nominally uncharged 180° domain walls in LiNbO is studied using second-harmonic generation microscopy and 3D polarimetry analysis.

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Discoidin domain receptors (DDRs) are one of the less explored targets for the treatment of cancer which belong to receptor tyrosine kinases family. Discoidin domain receptors (DDRs) are a collagen-activated receptor tyrosine kinase and essential for controlling cellular functions like proliferation, morphogenesis, adhesion, differentiation, invasion, matrix remodeling, and migration. Although there are many targets and their inhibitors are reported which treat cancer.

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Polyhydroxyalkanoates (PHA), especially poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is considered as the most suitable candidate to replace petrochemical plastics. However, the high production cost and the composition of the monomers in the copolymer are the major constraints in production. The 3-hydroxyvalerate (3HV) rich copolymers are ideal for various applications due to their lower melting points, improved elasticity, and ductility.

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Carbon capture technologies have advanced in recent years to meet the ever-increasing quest to minimize excessive anthropogenic CO emissions. The most promising option for CO control has been identified as carbon capture and storage. Among the numerous sorbents, char generated from biomass thermal conversion has shown to be an efficient CO adsorbent.

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The Crown-shaped, severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) triggered the globally fatal illness of Coronavirus disease-2019 (COVID-19). This infection is known to be initially reported in bats and has been causing major respiratory challenges. The primary symptoms of COVID-19 include fever, fatigue and dry cough.

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder with synovitis and articular pathology as its primary expositions. Leflunomide (Lfd) is an anti-rheumatic drug that is effective in the treatment of RA, but displays severe side effects upon prolonged systemic administration. Local therapy might represent a promising strategy to treat rheumatoid arthritis without eliciting systemic adverse effects.

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Xylitol is pentahydroxy sugar alcohol, existing in very trace amount in fruits and vegetables, and finds varied application in industries like food, pharmaceuticals, confectionaries, etc. and is of prime importance to health. Owing to its trace occurrence in nature and considerable increase in market demand that exceeds availability, alternate production through biotechnological and chemical approach is in process.

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The Aurora-kinase family comprises of cell cycle-regulated serine/threonine kinases playing a vital role during mitosis. Aurora-A kinase is involved in multiple mitotic events in cell cycle and is a major regulator of centrosome function during mitosis. Aurora-A is overexpressed in breast, lung, colon, ovarian, glial, and pancreatic cancer.

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Solid waste management (SWM) is a service of public health that is often understated in its significance. If a public health emergency like the COVID-19 outbreak exacerbates the SWM problem, its true importance as an imperative service becomes more apparent. The crisis triggered by the COVID-19 pandemic has changed the dynamics of waste generation globally in nearly every sector and has therefore raised the need for special attention.

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Antimony (Sb) is introduced into soils, sediments, and aquatic environments from various sources such as weathering of sulfide ores, leaching of mining wastes, and anthropogenic activities. High Sb concentrations are toxic to ecosystems and potentially to public health via the accumulation in food chain. Although Sb is poisonous and carcinogenic to humans, the exact mechanisms causing toxicity still remain unclear.

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Biochar has been of considerable importance for various environmental applications in recent years. It has exhibited substantial advantages like favourable structural and surface properties, easy process of preparation and widely available feedstocks. These set of exceptional properties make it an efficient, cost-effective and environment friendly source for diversified elimination of pollutants.

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The advancement and modernization of industries have provided numerous benefits to human life including diversification of manufacturing a wide range of products made from plastic materials, thereby leading to the generation of huge quantities of plastic waste. Owing to the increasing issues related with plastic waste, recycling methods have attracted much interest. Recycling not only protects the environment and resources for future generations but also reduces energy consumption and greenhouse gas emissions.

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