The CXCL12 SNPs and their haplotypes are associated with serum lipid traits.

The relationship among the single nucleotide polymorphisms (SNPs) of the C-X-C motif chemokine ligand 12 gene (CXCL12) and the serum lipid profiles in the Chinese population has rarely been described, especially in somewhat old-fashioned and isolated Maonan minority. The goal of the current study was to elucidate the connection among the CXCL12 rs501120 and rs1746048 SNPs, haplotypes, several environmental factors and serum lipid traits in the Maonan as well as Han populations. Genotyping of the two SNPs, gel electrophoresis and direct sequencing were accomplished in 1,494 distinct subjects (Maonan, 750 and Han, 744) using polymerase chain reaction and restriction fragment length polymorphism.

rs6882076 SNP Is Associated with Decreased Levels of Triglycerides and the Risk of Coronary Heart Disease and Ischemic Stroke.

: The T-cell immunoglobulin and mucin domain 4 gene () rs6882076 single nucleotide polymorphism (SNP) has been associated with serum total cholesterol, low-density lipoprotein cholesterol and triglycerides (TG) levels, but the results are inconsistent. Moreover, little is known about such association in Chinese populations. The aim of this study was to detect the association of the rs6882076 SNP and serum lipid levels and the risk of coronary heart disease (CHD) and ischemic stroke (IS) in a Southern Chinese Han population.

Association of the rs2929282 polymorphism and serum lipid profiles in two Chinese ethnic groups.

Little is known about the association of the single nucleotide polymorphism (SNP) of rs2929282 near the FERM domain containing 5 () and serum lipid profiles. The present study detected the association of the rs2929282 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations. Genotyping of the rs2929282 SNP in 1065 subjects of Jing and 1061 participants of Han peoples was performed by polymerase chain reaction and restriction fragment length polymorphism, and then confirmed by direct sequencing.

Association of the APOA1 rs964184 SNP and serum lipid traits in the Chinese Maonan and Han populations.

Background: Maonan nationality belongs to a mountain ethnic minority in China. Little is known about the association of apolipoprotein A1 gene (APOA1) rs964184 single nucleotide polymorphism (SNP) and serum lipid levels in this population. The aim of this study was to detect the association of the APOA1 rs964184 SNP and several environmental factors with serum lipid profiles in the Chinese Maonan and Han populations.

Association of the rs1532085 SNP and serum lipid traits in the Chinese Maonan and Han populations.

The hepatic lipase gene () is known to play an important role in lipid and lipoprotein metabolism pathways, but the association of the rs1532085 single nucleotide polymorphism (SNP) and serum lipid profiles has not been previously reported in different racial/ethnic groups. The present study was to detect the association of the rs1532085 SNP and several environmental factors with serum lipid levels in the Maonan and Han populations. Genotypes of the rs1532085 SNP in 833 individuals of Maonan nationality and 801 participants of Han nationality were determined by polymerase chain reaction and restriction fragment length polymorphism.

Association of the rs2068888 polymorphism and serum lipid traits in the Chinese Maonan and Han populations.

The cytochrome P450 protein plays an important role in the synthesis of cholesterol and other lipid parameters. But little is known about the association of the single nucleotide polymorphism (SNP) of rs2068888 near cytochrome P450 26A1 gene () and serum lipid profiles in the Chinese Maonan and Han populations. This study explored such association in the two populations.