Novel nickel-immobilized-SiO-TiO fine particles in the presence of cetyltrimethylammonium bromide as a catalyst for ultrasound-assisted-Kumada cross-coupling reaction.

Kumada cross-coupling reaction is useful for producing biphenyls, where nickel and copper have been widely investigated as catalysts but mainly homogeneous ones. In this study, we investigated ultrasound-assisted-Kumada cross-coupling reaction over the heterogeneous catalysts in which Ni, Cu, or both was immobilized on aminopropylsilane-functionalized-SiO-TiO prepared in the presence of cetyltrimethylammonium bromide (CTAB). The presence of CTAB effectively prevented the particle growth and therefore SiO-TiO fine particles with high surface area (502 m g) were formed.

Ultrasound-assisted-one-pot synthesis and antiplasmodium evaluation of 3-substituted-isoindolin-1-ones.

As the attempts to control malaria through chemotherapy strategies are restricted, we have prepared a small library of 3-substituted-isoindolinones from ()-3-benzylideneisobenzofuran-1(3)-ones in one-pot fashion under ultrasound irradiation. The one-pot reaction was scalable and efficiently produced the desired products (1a-m) in high yields in a short reaction time. Evaluation of their antiplasmodium assay against the 3D7 (chloroquine-sensitive) and FCR3 (chloroquine-resistant) strains of demonstrated that they displayed moderate to strong antiplasmodium activities (the IC values ranging from 4.