Expression of cyclin genes in human gastric cancer and in first degree relatives.

Objective: To clarify the role of these cyclins in human gastric cancer.

Methods: 38 gastric cancer patients, 29 first degree relatives of gastric cancer patients, as well as 18 healthy subjects were included. The mRNA expression of cyclins D1, D2, D3 and E in gastric biopsies was evaluated by RT-PCR analysis using specific primers.