Synthesis and characterization of core-shell magnetic molecularly imprinted polymer nanocomposites for the detection of interleukin-6.

Interleukin-6 (IL-6) belongs to the cytokine family and plays a vital role in regulating immune response, bone maintenance, body temperature adjustment, and cell growth. The overexpression of IL-6 can indicate various health complications, such as anastomotic leakage, cancer, and chronic diseases. Therefore, the availability of highly sensitive and specific biosensing platforms for IL-6 detection is critical.

Surface modification of PVDF ultrafiltration membranes using spacer arms and synthetic receptors for virus capturing and separation.

Although membrane technology has demonstrated outstanding pathogen removal capabilities, current commercial membranes are insufficient for removing small viruses at trace levels due to certain limitations. The theoretical and practical significance of developing a new form of hydrophilic, anti-fouling, and virus-specific ultra-purification membrane with high capturing and separation efficiency, stability, and throughput for water treatment is of the utmost importance. In this study, molecularly imprinted membranes (MIMs) were fabricated from polyvinylidene fluoride (PVDF) membranes utilizing novel surface hydrophilic modification techniques, followed by the immobilization of virus-specific molecularly imprinted nanoparticles (nanoMIPs) as synthetic receptors.

Computationally Designed Epitope-Mediated Imprinted Polymers versus Conventional Epitope Imprints for the Detection of Human Adenovirus in Water and Human Serum Samples.

Detection of pathogenic viruses for point-of-care applications has attracted great attention since the COVID-19 pandemic. Current virus diagnostic tools are laborious and expensive, while requiring medically trained staff. Although user-friendly and cost-effective biosensors are utilized for virus detection, many of them rely on recognition elements that suffer major drawbacks.

Current trends in COVID-19 diagnosis and its new variants in physiological fluids: Surface antigens, antibodies, nucleic acids, and RNA sequencing.

Rapid, highly sensitive, and accurate virus circulation monitoring techniques are critical to limit the spread of the virus and reduce the social and economic burden. Therefore, point-of-use diagnostic devices have played a critical role in addressing the outbreak of COVID-19 (SARS-CoV-2) viruses. This review provides a comprehensive overview of the current techniques developed for the detection of SARS-CoV-2 in various body fluids (e.

Cancer biomarker detection in human serum samples using nanoparticle decorated epitope-mediated hybrid MIP.

The determination of disease-associated molecules at trace amounts is a key factor for early and efficient diagnosis from human body fluids. Herein, an ultrasensitive electrochemical sensor based on hybrid epitope imprinting and nanomaterial amplification was developed. The hybrid epitope imprinting was achieved by electropolymerization in the presence of two computationally selected and cysteine modified epitopes of neuron specific enolase (NSE), as-synthesized gold nanoparticles (AuNPs), and functional monomer.

Ultrasensitive nonenzymatic electrochemical glucose sensor based on gold nanoparticles and molecularly imprinted polymers.

A non-enzymatic electrochemical glucose sensor with high sensitivity and selectivity was developed using gold nanoparticles-decorated molecularly imprinted polymers (AuNP-MIPs). The AuNP-MIPs were synthesized on a gold surface by multistep amperometry using the optimized conditions and in-house synthesized gold nanoparticles in the presence of glucose as the template. The AuNP-MIPs were investigated by employing atomic force microscopy (AFM), scanning electron microscopy (SEM) and electrochemical techniques to confirm successful fabrication of the sensor.

Significance of nanomaterials in electrochemical glucose sensors: An updated review (2016-2020).

The last decade has witnessed an immense demand for the development of new glucose biosensors. The research has mainly focused on achieving biocompatible and improved sensing capabilities as compared to the current technologies, which opens new directions toward more efficient glucose sensors. These sensing platforms have been continuously evolving with the contribution of novel materials, such as gold, platinum, metal alloys/adatom, graphene, composites and glucose-specific organic materials, owing to their electrocatalytic response to the oxidation of glucose.