Publications by authors named "Ekhlas Rahman"
Article Synopsis
- Interleukin 11 (IL11) was initially developed as a treatment for low platelet levels but has shown serious cardiac side effects, prompting researchers to investigate its toxic effects on heart cells for the first time.
- The study involved injecting recombinant IL11 into mice and using various scientific techniques to assess its effects on heart function and gene expression, revealing drastic reductions in heart performance and increased activation of inflammatory pathways.
- Findings from cardiomyocyte-specific knockout mouse models showed that IL11 directly induces stress responses and gene expression changes in heart cells, further solidifying its role in heart toxicity rather than protection.
Cardiac fibrosis is a common pathological process in heart disease, representing a therapeutic target. Transforming growth factor β (TGFβ) is the canonical driver of cardiac fibrosis and was recently shown to be dependent on interleukin 11 (IL11) for its profibrotic effects in fibroblasts. In the opposite direction, recombinant human IL11 has been reported as anti-fibrotic and anti-inflammatory in the mouse heart.
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