Publications by authors named "Ekaterina Zolotoverkhaya"
Trace amines and their receptors are a family of G protein-coupled receptors widely distributed in the central nervous system and periphery. The trace amine-associated receptor 1 (TAAR1) plays a significant role as a therapeutic target for schizophrenia, depression, diabetes, and obesity. In this study, TAAR1 knockout mice and WT groups were tested in conditions of a high-fructose diet.
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- Interest in trace amines and their receptors in mammals has increased over the past two decades, particularly regarding trace amine-associated receptor 9 (TAAR9), which is not well understood.
- Researchers created two new TAAR9 knockout (TAAR9-KO) rat strains using CRISPR-Cas9 to study the receptor's role in physiology.
- While most blood parameters remained unchanged, the study found significant decreases in total and low-density lipoprotein cholesterol levels in TAAR9-KO rats, suggesting a potential link between TAAR9 and cholesterol regulation.
Background: Cytology-based screening has significantly decreased incidence of and mortality from cervical cancer. High sensitivity of high-risk human papillomavirus (hrHPV) test for the detection of high-grade cervical intraepithelial neoplasia (CIN) makes it a useful screening tool, especially in settings where cytology is not available or not quality assured. The study aimed to determine the prevalence of hrHPV and associated cervical lesions in Russian women over 30 years of age and to assess usefulness of HPV test for cervical screening in Russia.
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