Publications by authors named "Ekaterina Vadachkoria"
Introduction: Up to 9.9% of children have fetal alcohol spectrum disorders (FASD), the most frequent cause of intellectual disability in the US. FASD may involve abnormal brain development, including dysmyelination, suggesting abnormal development of oligodendrocytes (OLs), which make myelin and are rich in lipids.
View Article and Find Full Text PDFArticle Synopsis
- - Fetal alcohol spectrum disorders (FASD) cause significant neurodevelopmental disabilities, but the exact mechanisms and genetic factors involved are not fully understood.
- - This study explored how alcohol exposure during fetal development affects ribosome biogenesis and the expression of short non-coding RNAs (srRNAs), revealing that ethanol slightly reduces srRNA levels and negatively impacts neuronal survival.
- - The research found that adding exogenous srRNAs can counteract the damaging effects of alcohol, improving cell survival and stabilizing srRNA levels, and that lower levels of 18S rRNA are linked to reduced fetal eye diameter, a characteristic of FASD.