Aurora kinases are essential players in mammalian cell division. These kinases are involved in the regulation of spindle dynamics, microtubule-kinetochore interactions, and chromosome condensation and orientation during mitosis. At least three members of the Aurora family - Aurora kinases A, B, and C - have been identified in mammals.
View Article and Find Full Text PDFNovel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained coumarins have been tested with -dodecaborate derivative bearing terminal alkynyl group.
View Article and Find Full Text PDFThe first examples of metallasilsesquioxane complexes, including ligands of the 8-hydroxyquinoline family -, were synthesized, and their structures were established by single crystal X-ray diffraction using synchrotron radiation. Compounds - tend to form a type of sandwich-like cage of CuM nuclearity (M = Li, Na, K). Each complex includes two cisoid pentameric silsesquioxane ligands and two 8-hydroxyquinoline ligands.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
September 2021
This article is devoted to the study of the tip shape of dendritic crystals grown from a supercooled liquid. The recently developed theory (Alexandrov & Galenko 2020 , 20190243. (doi:10.
View Article and Find Full Text PDFTwo stereoisomers of pentacoordinate iridium(III) hydridochloride with triptycene-based PC(sp)P pincer ligand (1,8-bis(diisopropylphosphino)triptycene), and , differ by the orientation of hydride ligand relative to the bridgehead ring of triptycene. According to DFT/B3PW91/def2-TZVP calculations performed, an equatorial Cl ligand can relatively easily change its position in , whereas that is not the case in . Both complexes and readily bind the sixth ligand to protect the empty coordination site.
View Article and Find Full Text PDFThe trinuclear copper(i) pyrazolate {[3,5-(CF3)2Pz]Cu}3 forms η2-copper/alkyne triple bond coordinated structures in the presence of acetylenes. There is no coordination of copper atoms to the phenyl ring of phenylacetylene and copper(i) acetylide formation during the interaction. It was observed that the complexes formed are the active catalytic species in click reactions.
View Article and Find Full Text PDFUnlabelled: Mitochondria are important regulators of tumour growth and progression due to their specific role in cancer metabolism and modulation of apoptotic pathways. In this paper we describe that mitochondria-targeted antioxidant SkQ1 designed as a conjugate of decyl-triphenylphosphonium cation (TPP) with plastoquinone, suppressed the growth of fibrosarcoma HT1080 and rhabdomyosarcoma RD tumour cells in culture and tumour growth of RD in xenograft nude mouse model. Under the same conditions, no detrimental effect of SkQ1 on cell growth of primary human subcutaneous fibroblasts was observed.
View Article and Find Full Text PDFPhilos Trans A Math Phys Eng Sci
February 2018
The boundary integral method for propagating solid/liquid interfaces is detailed with allowance for the thermo-solutal Stefan-type models. Two types of mass transfer mechanisms corresponding to the local equilibrium (parabolic-type equation) and local non-equilibrium (hyperbolic-type equation) solidification conditions are considered. A unified integro-differential equation for the curved interface is derived.
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